Table 4 List of differentially expressed genes at the third trimester of pregnancy associated with changes in depressive symptoms (from the third trimester to 2 months postpartum) at 5% FDR.

From: Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

Symbol

GnRHa_estradiol

Probe

Chr

P value_EPDSv2

FDR_EPDSv2

logFC_diffEPDSv2

P value_diffEPDSv2

FDR_diffEPDSv2

logFC_PPD

P value_PPD

FDR_PPD

logFC_Dep

P value_Dep

FDR_Dep

LOC100132062

 

100132062

NA

2.74E-59

3.52E-55

−0.09642385

1.86E-08

1.99E-05

−2.0794307

1.58E-33

1.01E-29

2.03759936

5.40E-19

6.94E-15

GSTA7P

 

730152

6

0.147252834

0.999797241

0.072537172

0.000661439

0.094343313

2.272172

1.65E-36

2.12E-32

−1.865593

1.46E-14

9.40E-11

SLC12A1

x

6557

15

0.738374001

0.999797241

−0.143662302

3.04E-23

3.91E-19

−1.5148531

3.68E-24

1.58E-20

1.52947173

1.01E-10

4.31E-07

FAM3B

 

54097

21

0.000506343

0.073862832

−0.081062951

4.36E-07

0.000357438

−1.2068425

2.86E-11

6.13E-08

1.29211562

4.09E-08

0.00013115

RAP1GAP

 

5909

1

0.000417001

0.066086904

−0.084706388

1.69E-09

2.71E-06

−0.7001112

1.09E-07

0.0001401

0.95024605

2.17E-06

0.00537669

MYOM2

 

9172

NA

0.558974564

0.999797241

0.045488778

0.002563317

0.19942602

0.66107629

8.04E-07

0.00077909

−0.9456007

2.51E-06

0.00537669

RNF182

 

221687

6

0.983664265

0.999797241

−0.08587623

5.84E-07

0.000441361

−0.8205146

1.54E-08

2.47E-05

0.9490668

7.75E-06

0.01421399

HBZ

 

3050

16

1.81E-13

7.73E-10

0.08198997

3.96E-11

8.47E-08

1.24062397

8.58E-19

2.75E-15

−0.8915749

1.76E-05

0.02832105

PRSS33

x

260429

16

1.82E-06

0.00101726

−0.017543158

0.204453261

0.961442886

0.66940149

7.80E-07

0.00077909

−0.8128711

3.66E-05

0.05215136

IFI27

 

3429

NA

0.491717731

0.999797241

0.088816879

2.79E-09

3.98E-06

1.07939383

5.46E-16

1.40E-12

−0.7622081

8.16E-05

0.10472842

PTGDR2

 

11251

11

0.07345098

0.999797241

−0.009817193

0.48417276

0.999245113

0.68209765

9.10E-07

0.00077909

−0.7728273

9.83E-05

0.11468724

C4BPA

x

722

1

2.91E-10

6.22E-07

−0.051502467

3.73E-06

0.002174605

−0.6400513

6.58E-06

0.00384058

0.82369396

0.00010817

0.11571456

MAPK8IP1P2

 

644172

NA

0.038012933

0.90051655

0.000303088

0.987530803

0.999245113

−0.9800435

2.22E-06

0.001679

0.97855722

0.00012366

0.12211055

SLC35F1

 

222553

6

0.012780901

0.533803126

−0.070659963

1.20E-07

0.000110253

0.89950392

2.61E-10

4.78E-07

−0.7774074

0.00015966

0.14639261

CMBL

 

134147

5

0.475930622

0.999797241

−0.033792967

0.036959174

0.639413638

−0.7375122

3.29E-06

0.00211048

0.74263329

0.00044747

0.36562804

SFRP2

 

6423

4

0.422133267

0.999797241

−0.019762377

0.182110005

0.957043264

−0.5742315

2.74E-05

0.01256455

0.70217911

0.00045572

0.36562804

GALNT15

 

117248

3

0.661378861

0.999797241

0.005687522

0.71076802

0.999245113

0.73127667

5.79E-07

0.00067543

−0.678052

0.00076939

0.57668405

ALOX15

 

246

17

0.006381561

0.367354704

−0.004218688

0.757440501

0.999245113

0.57396501

1.79E-05

0.00886108

−0.6573506

0.00080862

0.57668405

RAVER2

 

55225

1

0.122015102

0.999797241

0.026473215

0.082808829

0.811263458

0.73076056

8.57E-07

0.00077909

−0.6602258

0.00122902

0.83036233

HES6

 

55502

2

0.616984359

0.999797241

−0.023906291

0.104221966

0.860937819

0.78046567

2.83E-08

4.04E-05

−0.5834678

0.00300491

0.99997367

SPTBN4

x

57731

19

0.853952516

0.999797241

0.04814081

0.003906481

0.251997482

0.84111298

1.57E-06

0.00125925

−0.5715084

0.01091626

0.99997367

FIBCD1

 

84929

9

0.01477133

0.571957401

0.054000943

0.00016668

0.038903107

0.72292732

2.77E-06

0.00197483

−0.5574507

0.007439

0.99997367

OLR1

 

4973

12

0.137268091

0.999797241

−0.040708626

0.002826989

0.21222253

−0.6437111

3.00E-06

0.00202536

0.62579802

0.00157598

0.99997367

FAM83A

 

84985

8

6.56E-06

0.003005253

0.035483408

0.024659247

0.565101277

0.68242078

3.88E-06

0.00237108

−0.4020439

0.04915913

0.99997367

RSAD2

 

91543

2

0.001262375

0.135042605

−0.003101777

0.802973454

0.999245113

0.55847735

1.04E-05

0.00581173

−0.423053

0.02966682

0.99997367

NA

 

654341

NA

0.040041391

0.918606088

0.043642091

0.002347612

0.194240656

−0.5985625

1.47E-05

0.00779562

0.62713957

0.00188074

0.99997367

DDX11L10

 

100287029

16

0.027398604

0.771306761

0.019363117

0.196566971

0.961362007

−0.7114069

1.52E-05

0.00779562

0.60633309

0.00556542

0.99997367

NCAPG2

 

54892

NA

0.118956575

0.999797241

0.035486631

0.013137006

0.436890536

0.60702078

2.18E-05

0.01035033

−0.4730099

0.01883019

0.99997367

DEFA1B

 

728358

8

2.73E-09

3.90E-06

−0.082334647

2.83E-08

2.80E-05

0.53566102

5.17E-05

0.02287903

−0.505308

0.00958881

0.99997367

MMP8

 

4317

11

0.093862874

0.999797241

−0.042863638

0.001119109

0.133018019

−0.5140184

6.88E-05

0.02943342

0.50413614

0.00877009

0.99997367

NEBL

 

10529

10

0.177260886

0.999797241

−0.030514743

0.029510787

0.604610542

0.59512746

7.33E-05

0.03037117

−0.6234225

0.00358599

0.99997367

OR8U8

 

504189

NA

7.64E-05

0.020856842

0.042692465

0.000391896

0.065334587

0.51621139

9.78E-05

0.03924713

−0.3413738

0.08193914

0.99997367

CLC

 

1178

19

0.04198233

0.934015898

0.001050171

0.933703936

0.999245113

0.48764167

0.00010431

0.0405769

−0.5586975

0.00285235

0.99997367

SMIM1

 

388588

1

1.08E-05

0.004463077

−0.046924669

0.000526408

0.081415689

0.52234014

0.00011953

0.04456932

−0.2791593

0.15879646

0.99997367

ISG15

 

9636

1

0.335644265

0.999797241

0.016722871

0.173604797

0.957043264

0.49763474

0.00012152

0.04456932

−0.3898466

0.04277624

0.99997367

KIAA1324L

 

222223

7

0.940093172

0.999797241

0.011875341

0.433620456

0.999245113

−0.6272798

0.0001271

0.04532091

0.603388

0.00521569

0.99997367

ZFP57

x

346171

6

0.688934236

0.999797241

0.113752939

9.57E-12

3.07E-08

0.6292577

0.00014379

0.04988752

−0.6042326

0.0056805

0.99997367

TMEM176B

x

28959

7

0.003678342

0.266546287

−9.93E-05

0.993610049

0.999245113

0.48636354

0.00014793

0.04997309

−0.6027717

0.0021531

0.99997367

  1. EPDS Edinburgh Postnatal Depression Scale symptoms at 2 months postpartum, diffEPDS difference in EPDS symptoms from the third trimester of pregnancy to 2 months postpartum, PPD EPDS symptoms in the PPD group, Dep EPDS symptoms in the depression group, GnRHa_estradiol genes associated with estradiol in the GnRHa study, FDR P values after false discovery rate multiple testing.
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