Table 1 Overview of environmental factors.

From: Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Category	UKB ID	Full name	Short name	N	Type	Levels	Range
Physical health	2188	Long-standing illness, disability, or infirmity	Disability/infirmity	308,892	Ordinal	2	Yes–No
Physical health	23,104	Body mass index (BMI)	BMI	308,303	Continuous	–	12.8–68.4
Physical health	100,048	Pain types experienced for 3+ months*	Chronic pain	313,219	Count	4	0–3
Physical health	4548	Health satisfaction	Health satisf.	123,307	Ordinal	6	Extremely unhappy–…–Extremely happy
Physical health/Trauma	20,528	Diagnosed with a life-threatening illness	Terminal illness	106,089	Ordinal	3	Never–Yes, but not in the last 12 months–Yes, within the last 12 months
Trauma	20,531	Victim of sexual assault	Sexual assault	105,362	Ordinal	3	Never–Yes, but not in the last 12 months–Yes, within the last 12 months
Trauma	20,529	Victim of physically violent crime	Physical assault	106,257	Ordinal	3	Never–Yes, but not in the last 12 months–Yes, within the last 12 months
Trauma	6145	Illness, injury, bereavement, the stress in last 2 years	Multiple stress	312,278	Count	7	Serious illness, injury, or assault to yourself–…–Death of a close relative–…–None of the above
Trauma/Social support	20,488	Physically abused by family as a child	Child. physical abuse	106,240	Ordinal	5	Never true–…–Sometimes true– ...–Very often true
Trauma/Social support	20,487	Felt hated by a family member as a child	Felt hated	106,183	Ordinal	5	Never true–…–Sometimes true– ...–Very often true
Trauma/Social support	20,489	Felt loved as a child	Felt loved	106,098	Ordinal	5	Never true–…–Sometimes true– ...–Very often true
Social support	20,522	Been in a confiding relationship as an adult	Adult confiding rel.	104,073	Ordinal	5	Never true–…–Sometimes true– ...–Very often true
Social support	1031	Frequency of friend/family visits	Friend/family visits	312,492	Ordinal	7	No friends/family outside household–…–Almost daily
Social support	6160	Leisure/social activities	Social activities	312,940	Count	6	Sports club–…–Pub or social club –…–None of the above
Social support	2110	Able to confide	Able to confide	307,308	Ordinal	6	Never or almost never–…– Almost daily
Social support	4559	Family relationship satisfaction	Family satisf.	122,578	Ordinal	6	Extremely unhappy–…– Extremely happy
Social support	4570	Friendships satisfaction	Friendship satisf.	122,423	Ordinal	6	Extremely unhappy–…– Extremely happy
Sociodemographic	4537	Work/job satisfaction	Work satisf.	84,711	Ordinal	6	Extremely unhappy–…– Extremely happy
Sociodemographic	4581	Financial situation satisfaction	Financial satisf.	123,172	Ordinal	6	Extremely unhappy–…– Extremely happy
Sociodemographic	189	Townsend deprivation index at recruitment	TDI	313,108	Continuous	–	−6.26–11
Sociodemographic/Education	845	Age completed full-time education	Y/o schooling	203,479	Continuous	–	5–35
Cognitive function	20,016	Fluid intelligence score	Intelligence	120,422	Continuous	–	0–13
Sleep	1200	Sleeplessness/insomnia	Insomnia	313,321	Ordinal	3	Never/rarely–Sometimes– Usually
Substance use	1558	Alcohol intake frequency	Alcohol intake	313,339	Ordinal	6	Never–…–Daily or almost daily
Substance use	20,116	Smoking status	Smoking	312,638	Ordinal	3	Never–Previous–Current

628* = item constructed using multiple variables, the UKB ID is the UK Biobank category ID (see “Methods” section).

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Table 1 Overview of environmental factors.

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