Table 1 Local ancestry estimates in individuals of European ancestry for ancestral populations AFR, EAS and EUR.

From: HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

Ancestral population

Non-risk vs risk allele carriers

Non-risk allele carriers: controls vs cases

Dosage

Difference

P value

dosage

difference

P value

AFR

0.470/0.213

0.257

<1.00E−04

0.452/0.600

−0.148

1.20E−03

EAS

0.641/1.344

−0.703

<1.00E−04

0.668/0.452

0.216

<1.00E−04

EUR

0.889/0.443

0.446

<1.00E−04

0.881/0.948

−0.067

8.31E−02

AFR–EAS

−0.154/−0.726

0.573

<1.00E−04

−0.193/0.141

−0.334

<1.00E−04

AFR–EUR

−0.308/−0.351

0.043

3.40E−01

−0.322/−0.224

−0.098

5.77E−02

EAS–EUR

−0.162/0.504

−0.666

<1.00E−04

−0.138/−0.353

0.216

9.00E−04

  1. Dosage means for single ancestral populations and normed differences for two populations were compared between risk (N = 45) and non-risk allele (N = 956) carriers as well as between controls (N = 838) and neutropenia cases (N = 118) not carrying the risk allele. P values were determined by permutation tests (N = 10,000). Significant results are in bold.
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