Table 2 Results of association analyses of rs113332494 for neutropenia and agranulocytosis including 1004 and 925 individuals of European ancestry.

From: HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

Phenotype

N cases

N controls

Info

Freq cases

Freq controls

Global ancestry

Global and local ancestry

OR 95% CI

P value

OR 95% CI

P value

Neutropenia

133

871

0.962

0.054

0.018

6.20

2.20E−06

10.38

6.05E−08

2.91–13.21

4.45–24.22

Agranulocytosis

54

871

0.969

0.080

0.018

10.49

1.83E−06

16.31

1.39E−06

3.99–27.56

5.25–50.68

  1. Estimates are given for risk allele G. Global ancestry: association results corrected for principal components (PC1–PC7). Global and local ancestry: association results corrected for principal components (PC1–PC7) and local ancestry estimates for ancestral populations AFR and EAS. Significant results are in bold.
  2. Freq frequency of risk allele G, OR odds ratio for risk allele G, 95% CI 95% confidence interval for odds ratio.
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