Fig. 3: Anxiety-like behavior and escitalopram concetrations in dams and pups.
From: Moderation of the transgenerational transference of antenatal stress-induced anxiety
A Antenatal stress-induced anxiety-like behaviors in dams, on PND 1. n = 15 dams per group. B Antenatal stress had a lasting effect on dams’ anxiety-like behavior, which was ameliorated by chronic treatment with either escitalopram or shan-zha. n = 5 dams per group. C Dams treated with escitalopram demonstrated reduced [3H]citalopram binding compared to control- and shan-zha-treated dams, indicating increased serum escitalopram level. n = 4 dams per group. D Pups that were exposed to stress during gestation demonstrated increased anxiety-like behavior on PND 21; maternal treatment with either escitalopram or shan-zha ameliorated the anxiety-like phenotype. n = 35–39 pups per group. E Pups of dams that were treated with escitalopram demonstrated increased serum escitalopram levels. n = 14–16 pups per group. Dashed lines represent means of reference groups (i.e., control-naïve groups). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
