Table 5 Comparison of ARBs with ACEIs.
From: Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes
ARB vs ACEI (prior psychiatric diagnosis) | ARB vs ACEI (no prior psychiatric diagnosis) | ||||
|---|---|---|---|---|---|
Baseline characteristics | ARB | ACEI | ARB | ACEI | |
Number | 49,314 | 49,314 | 322,814 | 322,814 | |
Age at index (years) | 60.6 (12.8) | 60.6 (12.8) | 62.3 (12.4) | 62.4 (12.6) | |
Sex (M:F %) | 30:70 | 30:70 | 46:54 | 46:54 | |
Race (% W, B, O)a | 76, 15, 9 | 77, 15, 8 | 65, 16, 19 | 66, 16, 18 | |
Blood pressure | 135/78 | 135/78 | 137/78 | 137/78 | |
Outcomes | ICD-10 codes | % in each cohort (ARB, ACEI) | Risk ratio (95% CI) | % in each cohort (ARB, ACEI) | Risk ratio (95% CI) |
Psychotic disorder | F20-29 | 2.5, 4.0 | 0.61 (0.57–0.66) | 0.4, 0.7 | 0.57 (0.54–0.61) |
Schizophrenia | F20 | 0.9, 1.8 | 0.52 (0.46–0.58) | 0.08, 0.2 | 0.39 (0.33–0.45) |
Affective disorder | F30-39 | 45, 48 | 0.94 (0.93–0.95) | 8.7, 9.4 | 0.92 (0.91–0.94) |
Bipolar disorder | F30,31 | 4.0, 5.5 | 0.73 (0.69–0.77) | 0.4, 0.6 | 0.68 (0.63–0.73) |
Major depression | F32,33 | 40, 43 | 0.94 (0.93–0.96) | 7.9, 8.4 | 0.93 (0.92–0.95) |
Anxiety disorder | F40-48 | 44, 42 | 1.03 (1.02–1.05) | 9.2, 8.7 | 1.05 (1.03–1.06) |
Sleep disorder | F51, G47 | 32,29 | 1.13 (1.11–1.15) | 16, 13 | 1.22 (1.21–1.24) |
Substance use disorder | F10-19 | 14,21 | 0.66 (0.64–0.68) | 5.7, 9.5 | 0.60 (0.59–0.61) |
