Fig. 2: Insula volume and surface-features based on voxel-wise and vertex-based analyses.
From: Insula sub-regions across the psychosis spectrum: morphology and clinical correlates
To complement our region-of-interest analyses, we conducted voxel-wise (volume) and vertex-based (surface) analyses of insula structure in each cohort using explicit insula masks64,66. Group differences within the psychosis (healthy controls > psychosis) and PNC (typically developing > psychosis spectrum youth) cohorts are displayed. Mirroring and extending our region-of-interest analyses, psychotic disorder participants had reduced volume and gyrification and well as reduced cortical thickness. No significant group differences were observed in the PNC. Cluster-level corrected pFWE = 0.05 for voxel-wise p < 0.001 uncorrected, controlling for age, gender, total intracranial volume (TIV), study (for psychotic disorders cohort), and topography defects (for surface-based measures).
