Fig. 1: Overview of melatonin receptor-independent and receptor-dependent neuroprotective effects. | Translational Psychiatry

Fig. 1: Overview of melatonin receptor-independent and receptor-dependent neuroprotective effects.

From: Melatonin’s neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders

Fig. 1

Melatonin administration can elicit receptor-independent and dependent effects. Melatonin promotes anti-oxidant defenses and free-radical scavenging throughout the body. The relatively high levels of melatonin within mitochondria have the important benefit of enhanced protection against mtDNA damage and prevention of apoptosis.

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