Table 4 Associations between TLR4 cg05429895 methylation levels and affective score, HDRS and BDI in the Danish twin study, MARS, PReDICT and GRADY cohorts.
From: Toll-like receptor 4 methylation grade is linked to depressive symptom severity
Danish twin study | MARS (n = 213) | PReDICT (n = 321) | GRADY (n = 327) | |
|---|---|---|---|---|
Affective score beta; p value | ||||
All | −46.6; 0.005* | – | – | – |
Men | −65.4; 0.0006* | – | – | – |
Women | −24.2; 0.25 | – | – | – |
HDRS_1 beta; p value# | ||||
All | – | 0.001; 0.97 | 0.031; 0.13 | – |
Men | – | 0.041; 0.35 | 0.078; 0.01* | – |
Women | – | −0.021; 0.63 | 0.001; 0.96 | – |
HDRS_3 beta; p value# | ||||
All | – | 0.003; 0.86 | −0.0156; 0.35 | – |
Men | – | 0.024; 0.39 | 0.031; 0.27 | – |
Women | – | −0.007; 0.80 | −0.040; 0.059 | – |
BDI_01 beta; p value# | ||||
All | – | – | – | 0.018; 0.23 |
Men | – | – | – | 0.007; 0.82 |
Women | – | – | – | 0.016; 0.36 |
BDI_09 beta; p value# | ||||
All | – | – | – | 0.006; 0.86 |
Men | – | – | – | 0.093; 0.19 |
Women | – | – | – | −0.023; 0.53 |
