Table 3 The top GREAT ontology enrichments for regions potentially related to depression by using binomial test.
Ontology database | Term name | Binom FDR Q-value | Binom region fold enrichment |
|---|---|---|---|
Pathways | |||
PANTHER | Transcription regulation by bZIP transcription factor | 1.94E−24 | 3.18 |
PANTHER | Notch signaling pathway | 2.38E−07 | 1.81 |
PANTHER | Nicotine pharmacodynamics pathway | 5.88E−06 | 1.85 |
PANTHER | Huntington disease | 5.95E−06 | 1.38 |
PANTHER | p53 pathway by glucose deprivation | 7.56E−05 | 2.03 |
PANTHER | ATP synthesis | 7.44E−05 | 10.97 |
PANTHER | Parkinson disease | 7.32E−05 | 1.45 |
PANTHER | Hedgehog signaling pathway | 1.72E−04 | 1.76 |
PANTHER | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | 1.31E−03 | 1.37 |
PANTHER | Adrenaline and noradrenaline biosynthesis | 1.21E−02 | 1.59 |
BioCyc | Histidine degradation III | 8.26E−09 | 7.34 |
BioCyc | Palmitate biosynthesis I (animals) | 1.27E−08 | 3.92 |
BioCyc | Catecholamine biosynthesis | 1.09E−08 | 6.49 |
BioCyc | Adenine and adenosine salvage I | 2.15E−07 | 18.12 |
BioCyc | Aspartate biosynthesis | 2.86E−07 | 8.98 |
BioCyc | Methylglyoxal degradation VI | 4.68E−07 | 3.41 |
BioCyc | Oxidized GTP and dGTP detoxification | 6.76E−07 | 18.79 |
BioCyc | Hypusine biosynthesis | 8.58E−07 | 24.23 |
BioCyc | Serine and glycine biosynthesis | 2.47E−06 | 3.16 |
BioCyc | Dolichyl-diphosphooligosaccharide biosynthesis | 2.45E−06 | 3.50 |
MSigDB | Elongation arrest and recovery | 1.03E−43 | 6.52 |
MSigDB | Formation of tubulin folding intermediates by CCT/TriC | 6.80E−30 | 5.44 |
MSigDB | Notch signaling pathway | 5.63E−28 | 2.85 |
MSigDB | Prefoldin mediated transfer of substrate to CCT/TriC | 2.68E−26 | 4.43 |
MSigDB | Thrombin signaling through proteinase activated receptors (PARs) | 3.13E−25 | 3.45 |
MSigDB | Formation of RNA Pol II elongation complex | 3.55E−25 | 3.64 |
MSigDB | Glucagon signaling in metabolic regulation | 1.69E−24 | 2.84 |
MSigDB | PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase | 2.20E−23 | 2.67 |
MSigDB | Prostacyclin signaling through prostacyclin receptor | 4.70E−22 | 4.40 |
MSigDB | G alpha (12/13) signaling events | 3.12E−20 | 1.98 |
GO function | |||
GO-MF | DNA binding | 1.26E−114 | 1.36 |
GO-MF | Nucleic acid binding | 1.06E−97 | 1.27 |
GO-MF | Sequence-specific DNA binding transcription factor activity | 7.48E−98 | 1.46 |
GO-MF | Nucleic acid binding transcription factor activity | 9.13E−96 | 1.46 |
GO-MF | Sequence-specific DNA binding | 1.57E−90 | 1.54 |
GO-MF | Organic cyclic compound binding | 1.75E−87 | 1.18 |
GO-MF | Heterocyclic compound binding | 5.68E−87 | 1.18 |
GO-MF | Transcription regulatory region DNA binding | 4.84E−58 | 1.61 |
GO-MF | Regulatory region DNA binding | 1.72E−57 | 1.60 |
GO-MF | Transcription regulatory region sequence-specific DNA binding | 1.64E−53 | 1.85 |
GO-BP | RNA metabolic process | 1.71E−89 | 1.27 |
GO-BP | Gene expression | 8.91E−88 | 1.26 |
GO-BP | RNA biosynthetic process | 7.09E−87 | 1.30 |
GO-BP | Transcription, DNA-dependent | 7.90E−86 | 1.30 |
GO-BP | Regulation of macromolecule biosynthetic process | 2.51E−82 | 1.23 |
GO-BP | Nucleobase-containing compound biosynthetic process | 5.60E−82 | 1.28 |
GO-BP | Regulation of RNA biosynthetic process | 1.08E−81 | 1.24 |
GO-BP | Nucleic acid metabolic process | 1.56E−80 | 1.23 |
GO-BP | Organic cyclic compound biosynthetic process | 2.66E−79 | 1.26 |
GO-BP | Regulation of RNA metabolic process | 7.78E−79 | 1.23 |
