Fig. 2: Acoustic startle and pre-pulse inhibition. | Translational Psychiatry

Fig. 2: Acoustic startle and pre-pulse inhibition.

From: Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia

Fig. 2

The startle response to a series of 13 acoustic stimuli at 120 dB (a) and 105 dB (b) was significantly reduced in PWS-cr mice (n = 23) compared to their wild-type littermates (n = 31) (*p < 0.05, ***p < 0.001). Pre-pulse inhibition of the acoustic startle response was measured by presenting noises of 8 dB and 16 dB 70 ms before the pulses of 120 dB (c) and 105 (d). The pre-pulse inhibition data showed operational sensory-motor gating, which was not affected by genotype (PWS-cr = 23, WT = 31).

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