Table 1 Summary table comparing behavioural and cognitive findings in the PWS-IC and PWS-cr mouse model for Prader-Willi syndrome.

From: Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia

Behavioural domain and measures

 

Behaviour in PWS model compared to WT littermates

 
  

PWS-IC [17, 18]

PWS-cr

Anxiety

EPM % open arm

≡

≡

 

OF % centre

≡

≡

Activity

 

↓

≡

Sensory motor gating

Acoustic startle response

↑

↓

 

PPI of startle response

↓

≡

Attention (5-CSRTT)

Accuracy

↓

≡

 

Omissions

↑

≡

Impulse control (5-CSRTT, baseline)

 

≡

≡

  1. The PWS-IC mice exhibit a range of behavioural phenotypes of relevance to psychiatric illness, in particular increased startle response and decreased PPI, and reduced attention [17, 18]. Testing the PWS-cr mice in equivalent conditions (same genetic background, same behavioural equipment, testing rooms, and protocols) revealed no differences, apart from a reduction in acoustic startle response.
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