Table 1 The crucial genes associated with central nervous system development are hypermethylated in F1-GDM sperm and have a tendency to be downregulated (logFC <0) in the F2-GDM hippocampus.
From: Intrauterine hyperglycemia impairs memory across two generations
Symbol | RRBS of Sperm (F1-GDM vs. Ctrl) | Microarray of Hip (F2-GDM vs. Ctrl) | |||||
|---|---|---|---|---|---|---|---|
Start | End | mean Methy Ctrl | mean Methy F1-GDM | Element | logFC | adj. P value | |
Tubb2b | 34127486 | 34127641 | 16.03% | 81.88% | CDS | −3.0865 | 0.001 |
Htr7 | 35969594 | 35969756 | 7.22% | 73.70% | CDS 3′-UTR | −1.7638 | 0.249 |
Dlgap1 | 70516618 | 70516771 | 6.80% | 86.87% | CDS | −1.2927 | 0.186 |
Tanc1 | 59843298 | 59843455 | 65.81% | 81.41% | CDS | −1.1135 | 0.026 |
Zeb2 | 44988693 | 44988893 | 14.49% | 85.39% | CDS | −0.7887 | 0.645 |
Wnt5a | 28518390 | 28522909 | 26.62% | 76.36% | CDS Intron | −0.5713 | 0.211 |
Hoxb3 | 96345925 | 96346054 | 7.08% | 28.65% | CDS | −0.4266 | 0.644 |
Nfix | 84784452 | 84784657 | 27.85% | 45.75% | Intron | −0.2088 | 0.678 |
Nfix | 84704134 | 84704384 | 38.83% | 64.20% | Intron | −0.2088 | 0.678 |
Akap7 | 25251588 | 25251727 | 25.82% | 77.69% | Intron | −0.2014 | 0.529 |
Camk2b | 6010025 | 6010230 | 49.49% | 89.20% | Intron | −0.1977 | 0.253 |
