Fig. 2: Expression of NF-κB transcripts in the DLPFC of controls vs. schizophrenia.

Two studies have measured NF-κB pathway transcripts in the DLPFC of people with schizophrenia compared to unaffected, age-matched controls. A Volk et al. [11] report up-regulations at multiple levels of the pathway in schizophrenia while Murphy et al. [12] replicated only one of these findings (TNFR1) and found several down-regulations of the same NF-κB pathway transcripts in schizophrenia. B When high inflammation controls (individuals with elevated levels of pro-inflammatory mRNAs) were omitted from analyses in Murphy et al. [12], many (13 of 18) of the diagnostic comparisons in NF-κB pathway transcripts were consistent with those reported by Volk et al. [11]. Red boxes indicate shared findings between both studies.