Table 2 Baseline demographic and clinical characteristics of the discovery/validation and replication samples.

From: Genome-wide differentially methylated genes associated with posttraumatic stress disorder and longitudinal change in methylation in rape survivors

	Discovery/validation sample (n = 47)		Replication sample (n = 49)		Comparison of discovery/validation sample to replication sample
	n (%)	M (SD)	n (%)	M (SD)	χ²	z	p
Age^a	47 (100)	25.9 (5.4)	49 (100)	24.6 (5.5)		−1.3	0.178
Secondary education completed^b	32 (68.1)		25 (51)		2.9		0.089
Employed^b	13 (27.7)		9 (18.4)		1.2		0.279
In a relationship/married^b	38 (80.9)		38 (77.6)		0.2		0.691
BMI^a	47 (100)	26.0 (6.5)	49 (100)	25.8 (5.7)		−0.1	0.956
Smoker^b	5 (10.6)		7 (14.3)		0.3		0.589
HIV positive^b	27 (57.4)		19 (38.8)		3.4		0.067
On ARVs^b	12 (25.5)		14 (28.6)		0.1		0.738
On medications for STI^b	2 (4.3)		2 (4.1)		0.0		0.966
Other medication use^b,c	1 (2.1)		2 (4.1)		0.3		0.582
Childhood trauma score^a	47 (100)	17.2 (4.1)	49 (100)	16.2 (2.5)		−0.8	0.410
Neglect^b	23 (48.9)		18 (36.7)		1.5		0.227
Domestic violence^b	10 (21.3)		8 (16.3)		0.4		0.534
Emotional abuse^b	12 (25.5)		11 (22.4)		0.1		0.724
Physical abuse^b	18 (38.3)		19 (38.8)		0.0		0.962
Sexual abuse^b	10 (21.3)		11 (22.4)		0.0		0.890
Number of childhood traumas^a	47 (100)	1.6 (1.6)	49 (100)	1.4 (1.5)		−0.6	0.530
Number of lifetime traumas^a,d	47 (100)	1.6 (1.5)	49 (100)	1.13(1.2)		−1.7	0.092
Imprisonment^b	2 (4.3)		1 (2.0)		0.4		0.533
Civil unrest or war^b	3 (6.4)		1(2.0)		1.1		0.287
Serious injury^b	8 (17.0)		3 (6.1)		2.8		0.094
Being close to death^b	13 (27.7)		14 (28.6)		0.0		0.921
Murder of family/friend^b	12 (25.5)		4 (8.2)		5.2		0.022*
Unnatural death of family/friend^b	9 (19.1)		5 (10.2)		1.5		0.214
Murder of stranger^b	10 (21.3)		5 (10.2)		2.2		0.135
Robbed with gun/knife used^b	17 (36.2)		18 (36.7)		0.0		0.954
Kidnaped^b	3 (6.4)		4 (8.2)		0.1		0.737
PTSD symptom score^a	47 (100)	67.1 (21.7)	49 (100)	65.7 (18.6)		−0.8	0.431
Alcohol use severity score^a	47 (100)	1.4 (2.2)	49 (100)	1.9 (2.5)		−1.2	0.242
Hazardous alcohol use^b	12 (25.5)		15 (30.6)		0.3		0.580
Depression symptom score^a	47 (100)	32.4 (13.9)	49(100)	31.7 (12.1)		−0.2	0.854
Depression status^b	41 (87.2)		45 (91.8)		0.5		0.461

PTSD Posttaumatic stress disorder, M mean, SD standard deviation, BMI body mass index, ARV antiretrovirals, STI sexually transmitted infection.
^aContinous variables.
^bCategorical variables.
^cMedication prescribed for chronic sinusitis (n = 1) and hypertension (n = 2).
^dLifetime traumas refer to directly experiencing the trauma; *p < 0.05.

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Table 2 Baseline demographic and clinical characteristics of the discovery/validation and replication samples.

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