Table 5 Summary statistics of the mixed regression models investigating baseline BRSK2 and ADCYAP1 methylation as predictors of change in posttraumatic stress symptoms scores over time.

From: Genome-wide differentially methylated genes associated with posttraumatic stress disorder and longitudinal change in methylation in rape survivors

Model		ß	Std error	t	p	95% CI
Model		ß	Std error	t	p	Lower	Upper
	Baseline BRSK2 CpG3 methylation
1A	Baseline × CpG3 (baseline)	0.07	0.10	0.71	0.482	−0.13	0.27
	3-months × CpG3 (baseline)	−0.39	0.10	−3.81	0.0002*	−0.60	−0.19
	6-months × CpG3 (baseline)	−0.49	0.10	−4.76	0.000004*	−0.70	−0.29
1B	Baseline × CpG3 (baseline)	−0.12	0.10	−1.17	0.247	−0.33	0.08
	3-months × CpG3 (baseline)	−0.16	0.15	−1.09	0.276	−0.45	0.13
	6-months × CpG3 (baseline)	−0.12	0.15	−0.81	0.418	−0.41	0.17
	Baseline × childhood trauma	1.54	0.49	3.13	0.002*	0.57	2.51
	3-months × childhood trauma	1.21	0.66	1.84	0.069	−0.09	2.52
	6-months × childhood trauma	−035	0.66	−0.53	0.598	−1.65	0.96
	Baseline × alcohol consumption	−1.36	0.76	−1.79	0.077	−2.87	0.15
	3-months × alcohol consumption	−0.96	1.23	−0.78	0.438	−3.40	1.48
	6-months × alcohol consumption	−1.65	1.23	−1.35	0.181	−4.09	0.78
	Baseline × depression	0.73	0.14	5.29	0.0000008*	0.46	1.01
	3-months × depression	0.00	0.22	0.00	1.00	−0.45	0.45
	6-months × depression	0.49	0.22	2.19	0.031*	0.05	0.93
1C	Baseline × CpG3 (baseline)	−0.10	0.10	−1.01	0.314	−0.31	0.10
	3-months × CpG3 (baseline)	−0.15	0.15	−1.03	0.305	−0.44	0.14
	6-months × CpG3 (baseline)	−0.10	0.15	−0.68	0.496	−0.39	0.19
	Baseline × childhood trauma	1.12	0.52	2.45	0.016*	0.24	2.30
	3-months × childhood trauma	1.12	0.73	1.54	0.126	−0.32	2.56
	6-months × childhood trauma	−0.67	0.72	−0.93	0.355	−2.10	0.76
	Baseline × alcohol consumption	−1.40	0.76	−1.85	0.067	−2.90	0.10
	3-months × alcohol consumption	−0.98	1.24	−0.79	0.432	−3.43	1.48
	6-months × alcohol consumption	−1.70	1.23	−1.38	0.170	−4.13	0.73
	Baseline × depression	0.77	0.14	5.50	0.0000003*	0.49	1.04
	3-months × depression	0.01	0.23	0.06	0.952	−0.44	0.47
	6-months × depression	0.53	0.23	2.35	0.021*	0.08	0.98
	Baseline × lifetime trauma	2.06	1.36	1.51	0.134	−0.65	4.76
	3-months × lifetime trauma	0.79	2.24	0.35	0.727	−3.66	5.23
	6-months × lifetime trauma	2.47	2.22	1.11	0.270	−1.95	6.88
	Baseline BRSK2 CpG4 methylation
2A	Baseline × CpG4 (baseline)	0.07	0.11	0.59	0.558	−0.16	0.29
	3-months × CpG4 (baseline)	−0.33	0.12	−2.85	0.005*	−0.56	−0.10
	6-months × CpG4 (baseline)	−0.44	0.12	−3.83	0.0002*	−0.67	−0.21
2B	Baseline × CpG4 (baseline)	−0.08	0.12	−0.70	0.486	−0.31	0.15
	3-months × CpG4 (baseline)	−0.14	0.15	−0.93	0.357	−0.44	0.16
	6-months × CpG4 (baseline)	−0.19	0.15	−1.29	0.201	−0.49	0.10
	Baseline × childhood trauma	1.44	0.51	2.84	0.005*	0.43	2.44
	3-months × childhood trauma	1.20	0.70	1.73	0.086	−0.17	2.58
	6-months × childhood trauma	−0.09	0.69	−0.12	0.902	−1.45	1.28
	Baseline × alcohol consumption	−1.41	0.77	−1.84	0.069	−2.93	0.11
	3-months × alcohol consumption	−1.00	1.23	−0.81	0.421	−3.44	1.45
	6-months × alcohol consumption	−1.60	1.22	−1.32	0.191	−4.02	0.82
	Baseline × depression	0.71	0.14	5.08	0.000002*	0.43	0.98
	3-months × depression	−0.01	0.23	−0.05	0.963	−0.46	0.44
	6-months × depression	0.53	0.22	2.40	0.018*	0.09	0.98
2C	Baseline × CpG4 (baseline)	−0.04	0.12	−0.36	0.720	−0.27	0.19
	3-months × CpG4 (baseline)	−0.12	0.16	−0.75	0.458	−0.42	0.19
	6-months × CpG4 (baseline)	−0.16	0.15	−1.01	0.314	−0.46	0.15
	Baseline × childhood trauma	1.20	0.53	2.24	0.027*	0.14	2.25
	3-months × childhood trauma	1.17	0.77	1.53	0.130	−0.35	2.69
	6-months × childhood trauma	−0.34	0.76	−0.45	0.654	−1.84	1.16
	Baseline × alcohol consumption	−1.47	0.76	−1.93	0.056	−2.99	0.04
	3-months × alcohol consumption	−1.03	1.24	−0.83	0.407	−3.49	1.43
	6-months × alcohol consumption	−1.67	1.22	−1.37	0.175	−4.09	0.75
	Baseline × depression	0.74	0.14	5.28	0.0000008*	0.46	1.02
	3-months × depression	0.00	0.23	0.01	0.996	−0.45	0.46
	6-months × depression	0.57	0.22	2.52	0.013*	0.12	1.01
	Baseline × lifetime trauma	2.11	1.39	1.52	0.132	−0.65	4.88
	3-months × lifetime trauma	0.71	2.27	0.32	0.753	−3.79	5.22
	6-months × lifetime trauma	2.19	2.23	0.98	0.329	−2.24	6.62
	Baseline BRSK2 CpG5 methylation
3A	Baseline × CpG5 (baseline)	0.16	0.10	1.60	0.112	−0.04	0.35
	3-months × CpG5 (baseline)	−0.27	0.10	−2.66	0.009*	−0.47	−0.07
	6-months × CpG5 (baseline)	−0.38	0.10	−3.73	0.0003*	−0.58	−0.18
3B	Baseline × CpG5 (baseline)	−0.06	0.10	−0.57	0.573	−0.25	0.14
	3-months × CpG5 (baseline)	−0.12	0.14	−0.84	0.405	−0.39	0.16
	6-months × CpG5 (baseline)	−0.06	0.14	−0.44	0.657	−0.33	0.21
	Baseline × childhood trauma	1.60	0.50	3.21	0.002*	0.61	2.58
	3-months × childhood trauma	1.33	0.66	2.01	0.047*	0.02	2.65
	6-months × childhood trauma	−0.27	0.66	−0.41	0.683	−1.58	1.04
	Baseline × alcohol consumption	−1.44	0.77	−1.88	0.064	−2.96	0.08
	3-months × alcohol consumption	−1.01	1.23	−0.82	0.412	−3.46	1.43
	6-months × alcohol consumption	−1.72	1.23	−1.41	0.163	−4.16	0.71
	Baseline × depression	0.72	0.14	5.13	0.000002*	0.44	1.00
	3-months × depression	0.00	0.23	0.01	0.991	−0.45	0.45
	6-months × depression	0.48	0.22	2.14	0.035*	0.03	0.93
3C	Baseline × CpG5 (baseline)	−0.03	0.10	−0.29	0.774	−0.23	0.17
	3-months × CpG5 (baseline)	−0.10	0.14	−0.71	0.477	−038	0.18
	6-months × CpG5 (baseline)	−0.03	0.14	−0.22	0.827	−0.31	0.25
	Baseline × childhood trauma	1.34	0.53	2.56	0.012*	0.30	2.39
	3-months × childhood trauma	1.28	0.73	1.74	0.085	−0.18	2.73
	6-months × childhood trauma	−0.58	0.73	−0.80	0.425	−2.03	0.86
	Baseline × alcohol consumption	−1.49	0.76	−1.96	0.054	−3.01	0.02
	3-months × alcohol consumption	−1.04	1.24	−0.84	0.402	−3.50	1.41
	6-months × alcohol consumption	−1.78	1.22	−1.46	0.148	−4.21	0.65
	Baseline × depression	0.75	0.14	5.33	0.0000007*	0.47	1.03
	3-months × depression	0.01	0.23	0.06	0.950	−0.44	0.47
	6-months × depression	0.52	0.23	2.29	0.024*	0.07	0.97
	Baseline × lifetime trauma	2.12	1.39	1.53	0.129	−0.63	4.88
	3-months × lifetime trauma	0.74	2.26	0.33	0.75	−3.74	5.22
	6-months × lifetime trauma	2.52	2.23	1.13	0.262	−1.92	6.96
	Baseline ADCYAP1 CpG1&2 methylation
4A	Baseline × CpG1&2 (baseline)	5.34	1.02	5.26	0.0000009*	3.33	7.36
	3-months × CpG1&2 (baseline)	−1.03	1.12	−0.92	0.360	−3.25	1.19
	6-months × CpG1&2 (baseline)	−3.52	1.18	−2.97	0.004*	−5.86	−1.17
4B	Baseline × CpG1&2 (baseline)	−0.73	0.88	−0.83	0.407	−2.47	1.01
	3-months × CpG1&2 (baseline)	2.75	1.39	1.98	0.050	−0.00	5.50
	6-months × CpG1&2 (baseline)	1.66	1.39	1.20	0.235	−1.10	4.41
	Baseline × childhood trauma	1.84	0.47	3.95	0.0001*	0.92	2.76
	3-months × childhood trauma	1.11	0.59	1.88	0.062	−0.05	2.26
	6-months × childhood trauma	−0.29	0.59	−0.49	0.625	−1.45	0.87
	Baseline × alcohol consumption	−1.48	0.77	−1.93	0.057	−3.01	0.05
	3-months × alcohol consumption	−1.43	1.22	−1.18	0.242	−3.85	0.98
	6-months × alcohol consumption	−1.91	1.21	−1.57	0.120	−4.32	0.51
	Baseline × depression	0.73	0.14	5.29	0.0000008*	0.46	1.01
	3-months × depression	−0.13	0.22	−0.59	0.554	−0.56	0.30
	6-months × depression	0.42	0.22	1.96	0.052	−0.00	0.85
4C	Baseline × CpG1&2 (baseline)	−0.54	0.89	−0.61	0.541	−2.30	1.22
	3-months × CpG1&2 (baseline)	2.76	1.42	1.95	0.055	−0.05	5.57
	6-months × CpG1&2 (baseline)	1.59	1.41	1.13	0.263	−1.22	4.40
	Baseline × childhood trauma	1.87	0.47	4.01	0.0001*	0.95	2.80
	3-months × childhood trauma	1.06	0.59	1.79	0.076	−0.11	2.24
	6-months × childhood trauma	−0.36	0.59	−0.60	0.550	−1.53	0.82
	Baseline × alcohol consumption	−1.44	0.76	−1.88	0.063	−2.96	0.08
	3-months × alcohol consumption	−1.43	1.22	−1.17	0.247	−3.86	1.01
	6-months × alcohol consumption	−1.91	1.22	−1.56	0.121	−4.34	0.52
	Baseline × depression	0.74	0.14	5.33	0.0000006*	0.46	1.01
	3-months × depression	−0.13	0.22	−0.61	0.546	−0.56	0.30
	6-months × depression	0.42	0.22	1.92	0.058	−0.01	0.85
	Baseline × HIV status	−4.51	3.54	−1.27	0.206	−11.55	2.53
	3-months × HIV status	−0.39	5.65	−0.07	0.945	−11.61	10.84
	6-months × HIV status	1.24	5.65	0.22	0.827	−9.99	12.46

CI confidence interval, BRSK2 brain-specific serine/threonine-protein kinase 2, ADCYAP1 adenylate cyclase activating polypeptide 1.

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Table 5 Summary statistics of the mixed regression models investigating baseline BRSK2 and ADCYAP1 methylation as predictors of change in posttraumatic stress symptoms scores over time.

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