Translational Psychiatry

Table 1 Regression analysis of polygenic scores and cognitive performance across gene-sets in the discovery and UK Biobank sample.

From: Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls

		Microglia				Neurons				Astroglia
	F change	R² change	β	p	F change	R² change	β	p	F change	R² change	β	p
Discovery sample
Full-scale IQ	6.62	0.008	−0.089	0.010	13.17	0.015	−0.124	<0.001	1.05	0.001	−0.038	0.306
Performance IQ	7.73	0.009	−0.096	0.006	11.61	0.013	−0.116	0.001	2.46	0.003	−0.058	0.117
Verbal IQ	4.78	0.005	−0.070	0.029	10.38	0.010	−0.101	0.001	0.44	0.001	−0.024	0.507
WTAR	1.84	0.002	−0.047	0.176	7.56	0.009	−0.095	0.006	0.01	0.001	0.000	0.909
LNS	5.47	0.006	−0.075	0.020	0.52	0.001	−0.023	0.472	4.37	0.006	−0.078	0.037
Spatial WM	2.37	0.003	−0.058	0.124	3.81	0.005	−0.073	0.051	0.63	0.001	−0.032	0.427
Episodic memory	13.70	0.018	−0.135	<0.001	8.17	0.011	−0.104	0.004	4.95	0.008	−0.087	0.027
UKB replication
Fluid intelligence	21.08	0.00018	−0.013	<0.001	30.73	0.000263	−0.016	<0.001	19.44	0.00016	−0.013	<0.001
Numerical memory	0.405	0.00001	−0.003	0.525	0.098	0.000002	0.002	0.755	0.24	0.000006	−0.002	0.627
Symbol-digit	19.05	0.00036	−0.019	<0.001	21.26	0.000400	−0.012	<0.001	11.22	0.00021	−0.015	0.001
General cognition	5.45	0.00016	−0.013	0.020	4.77	0.000143	−0.013	0.029	2.98	0.00009	−0.009	0.084

WTAR Wechsler test of adult reading, LNS letter-number sequencing, Spatial WM spatial working memory.

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