Table 1 Summary statistics of the cognitive tests in the UHR samples by conversion status.

From: Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

 

# samples

UHR-C

UHR-NC

Two-sample comparisona

 
 

(N = 93)

(N = 32)

(N = 61)

  
 

with values

Mean ± SD

Mean ± SD

t

P

Demographics

     

 Male

56

25

31

5.44

0.02

 Female

37

7

30

  

 Age

93

19.7 ± 2.6

21.9 ± 3.6

−3.01

0.003

Baseline symptoms

 BPRS

93

52.5 ± 11.5

54.1 ± 12.8

−0.60

0.55

 MADRS

93

21.8 ± 8.9

21.8 ± 10.4

0.03

0.98

 PANSS

93

70.4 ± 14.8

68.7 ± 17.8

0.47

0.64

 SOFAS

93

46 ± 9.6

46.6 ± 9

−0.30

0.76

WAIS scales

 FIQ

92

98.3 ± 12.8

106.3 ± 13.9

−2.70

0.01

 PIQ

81

95.6 ± 14.1

100.9 ± 13.2

−1.70

0.09

 VIQ

80

100.2 ± 11.7

106.5 ± 13.2

−2.11

0.04

Indices scores

 Verbal communication index

90

105.9 ± 13.8

112.6 ± 14.5

−2.08

0.04

 Working memory index

47

93.5 ± 14.1

106 ± 16.6

−2.73

0.01

 Perceptual organization index

90

97.8 ± 12.4

103.1 ± 13.5

−1.80

0.07

Subtests scores

 Arithmetic

90

9.5 ± 2.2

10 ± 3.3

−0.83

0.41

 Coding

90

8.9 ± 3.1

9.5 ± 3.3

−0.85

0.40

 Picture completion

78

10 ± 2.8

10.8 ± 2.3

−1.46

0.15

 Block design

90

9.6 ± 3

10.4 ± 3.5

−1.00

0.32

 Information

90

10.4 ± 2.8

11.6 ± 3.2

−1.76

0.08

 Matrix reasoning

90

9.6 ± 2.9

10.5 ± 2.9

−1.44

0.15

 Digit span

90

8.9 ± 3.3

9.9 ± 3.4

−1.25

0.22

 Similarities

90

11.2 ± 3.1

12.3 ± 2.7

−1.68

0.10

 Vocabulary

90

11.7 ± 2.5

12.8 ± 3.1

−1.71

0.09

Other cognitive tests

 D2 attention

48

99.3 ± 8.5

101.5 ± 9.3

−0.84

0.40

 Verbal fluency semantic animals

89

−0.4 ± 0.9

−0.2 ± 0.6

−1.37

0.17

 Verbal fluency phonologic letter p

89

0.4 ± 1.1

0.6 ± 0.9

−0.85

0.40

 TMT B minus TMT A

90

1.6 ± 1.6

0.8 ± 1.3

2.63

0.01

 Stroop Temps Inter Deno

47

0.4 ± 1.3

0.1 ± 1.3

0.75

0.46

 WCST percentage perseverative errors

92

51.7 ± 8.5

53.2 ± 10.3

−0.72

0.48

  1. N: samples with non-missing values UHR-C: ultra-high risk individuals who will convert to psychosis UHR-NC: ultra-high risk individuals who will not convert to psychosis.
  2. Symptoms at baseline including: BPRS brief psychiatric rating scale use to measure psychiatric symptoms such as depression, anxiety, hallucinations and unusual behavior, MADRS Montgomery Asberg depression rating scale self-assessment, PANSS Positive and Negative Syndrome Scale, and SOFAS social and occupational functioning assessment scale.
  3. SD standard deviation.
  4. aThe comparison are based on T-test, except for sex comparison which used chi-square test. P values < 0.05 for these test are highlighted in bold.
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