Table 2 Linear regression of full WAIS IQ on PRS adjusted on age, sex and population structure.

From: Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

FIQ ~ PRS GWAS

GWAS SS

P-val-T

ES*

SE*

R2

R2a*

P

FDR P

Schizophrenia

150 064

0.1

−0.296

0.120

0.169

0.049

0.016

0.048

Schizophrenia resilience

66 617

0.01

0.350

0.114

0.197

0.081

0.003

0.014

ADHD

55 374

1.0E−07

0.136

0.104

0.129

0.003

0.197

0.222

Bipolar disorder

51 710

0.1

−0.250

0.190

0.130

0.004

0.191

0.222

Major depression

480 359

1.0E−05

−0.215

0.113

0.147

0.024

0.061

0.110

Cross-disorder 2

727 126

1.0E−03

0.073

0.108

0.117

-0.010

0.500

0.500

Intelligence

269 867

1.0E−04

0.198

0.104

0.147

0.024

0.060

0.110

Educational attainment

766 345

1.0E−06

0.178

0.101

0.142

0.018

0.081

0.122

Cognitive performance

257 828

0.3

0.349

0.102

0.216

0.102

0.001

0.009

  1. GWAS SS: discovery sample size of the GWAS.
  2. P-val-T: best fit p value threshold.
  3. ES: effect size (coefficient in the linear regression model after stardardizing the variables).
  4. R2a: adjusted R square, the variance explained by PRS. P values and corrected P values (FDR P) are highlighted in bold if they are < 0.05.
  5. ADHD attention deficit hyperactivity disorder, SE standard error.
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