Fig. 1: The APOE ε4 allele-induced increase in depression-like behaviors in an age-dependent manner.
From: APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Depression-like behavior measurements of apoE3-TR and apoE4-TR mice at 3, 8, and 18 months of age, including sucrose consumption percentage in SPT (A), immobility time in the TST (B), locomotion in the open field (C). *p < 0.05, **p < 0.01, by two-way ANOVA with Tukey’s Multiple Comparisons Test (n = 13–16). D The time line of FST and behavioral test of apoE3-TR and apoE4-TR mice at 3, 8 months of age. E The immobility time in the forced swim test (FST). *p < 0.05, **p < 0.01, ***p < 0.001, by two-way ANOVA with Tukey’s Multiple Comparisons Test (n = 8–13). F The reconstruction of PET-CT images demonstrated a remarkable MPPF uptake in the hippocampus. G Hippocampus standard intake value (SUV) chart, *p < 0.05, **p < 0.01, ***p < 0.001, by two-way ANOVA with Tukey’s Multiple Comparisons Test (n = 7–8). NS not significant (p > 0.05). Data are presented as the mean ± S.E.M.
