Fig. 6: Increased susceptibility to chemically induced seizures in mice lacking Nrp2.
From: Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2
A Representative baseline EEG traces (left) and EEG traces following KA injection (right) show development of electrographic seizures in Nrp2+/+ (top), Nrp2+/− (middle), and Nrp2−/− (bottom) mice during the first 30 min following injection of Kainic acid (25 mg/kg). B Latency to first convulsive seizure following KA inj. Note that Nrp2−/− mice (n = 5) develop convulsive seizures significantly faster than Nrp2+/− (n = 6), Nrp2+/+ (n = 6) mice. C Cumulative seizures score indicates severity of behavioral seizures scored using the modified Racine scale. D Time to first convulsive seizure following KA injection. *indicates p < 0.05 by pairwise comparison using Dunn test, following Kruskal–Wallis rank-sum test E Total duration of electrographic seizures in the first 30 min after KA inj shows that that Nrp2−/− mice spend significantly longer duration seizing compared to Nrp2+/+, Nrp2+/− mice. *indicate p < 0.05 by one-way ANOVA, post hoc Tukey’s pairwise comparison.
