Fig. 7: Nrp2-deficient mice have impaired cognitive flexibility as seen in an operant reward-based reversal-learning task.
From: Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2
A Schematic illustration of the reversal-learning task. Mice chose between two levers for a food reward. Responses on each trial were categorized as “win” or “loss” and “stay” or “shift” based on the previous trial’s choice and outcome. B The lose-shift ratio was significantly reduced in Nrp2−/− and Nrp2+/− compared to Nrp2+/+ mice. C) No significant differences between genotypes were found for the win-stay ratio. Error bars are ± SEM; one-way ANOVA, post hoc Tukey: *p = 0.0320 + /+ vs. −/−, *p = 0.0496 + /+ vs. +/−, and ns p = 0.9669, n = 5 animals/genotype.
