Table 2 Effect sizes and p-values of significant CpG sites for each depression variable.

A. Primary outcomes: Maternal depression scores and newborn DNAm
CpG Site	Chromosome: Position	Variable	Δ beta per IQR^d	Standard Error	P-value
cg16473797^a	chr20:61755045	EPDS Continuous	−1.06E-02	2.12E-04	1.04E-03
cg16473797^a	chr20:61755045	BDI-II Continuous	−5.64E-03	9.19E-05	5.72E-05
cg23262030^a	chr17:45918702	EPDS Continuous	1.71E-03	4.21E-05	7.87E-03
cg23262030^a	chr17:45918702	BDI-II Continuous	1.47E-03	1.82E-05	1.18E-07
cg04859497^b	chr2: 79923818	EPDS Continuous	−3.88E-02	1.05E-03	0.459
cg04859497^b	chr2: 79923818	BDI-II Continuous	−2.85E-02	4.01E-04	3.61E-07
B. Secondary outcomes: Screening for maternal depression and newborn DNAm
CpG Site	Chromosome: Position	Variable	Δ beta^e	Standard Error	P-value
cg16473797^a	chr20:61755045	EPDS Threshold 10	−1.32E-03	1.55E-03	0.39
		EPDS Threshold 13	−7.09E-03	2.38E-03	2.38E-03
		BDI-II Threshold 14	−1.10E-02	2.04E-03	6.87E-08
		BDI-II Threshold 20	−8.61E-03	2.29E-03	1.72E-04
cg23262030^a	chr17:45918702	EPDS Threshold 10	6.94E-04	4.18E-04	9.7E-02
		EPDS Threshold 13	1.06E-03	4.44E-04	1.7E-02
		BDI-II Threshold 14	1.90E-03	4.10E-04	3.76E-06
		BDI-II Threshold 20	1.40E-03	5.01E-04	5.01E-03
cg04859497^b	chr2: 79923818	EPDS Threshold 10	−9.15E-03	1.00E-02	0.359
		EPDS Threshold 13	−8.34E-03	1.08E-02	0.437
		BDI-II Threshold 14	−3.25E-02	9.15E-03	3.84E-04
		BDI-II Threshold 20	−6.42E-02	1.05E-02	1.06E-09^c

^aResults from the meta-analysis
^bResults from the EPIC array EWAS
^cBonferroni threshold for meta-analysis: 1.29 × 10⁻⁷, for EPIC EWAS: 6.40 × 10⁻⁸
^dΔ beta per IQR: This coefficient represents the increase of mean DNAm beta values per increase of one interquartile range (IQR) in the depression scores (EPDS or BDI Continuous). (IQR EPDS total for total participants = 6, IQR BDI-II total for total participants = 15.25, IQR EPDS total for EPIC array participants = 5, IQR BDI-II total for EPIC array participants = 14). Negative coefficients refer to smaller mean DNAm beta values in children of mothers with higher depression scores and positive coefficients refer to larger mean DNAm beta values in children of mothers with higher depression scores.
^eΔ beta: This coefficient represents the mean difference of DNAm beta values between children of mothers who were screened positive for depression verses of those who were not. Negative coefficients refer to smaller mean DNAm beta values in children of mothers who were screened positive and positive coefficients refer to larger mean DNAm beta values in children of mothers who were screened positive for depression.

Search