Table 3 Max effect sizes and p-values from a meta-analysis using DMRcate for DMRs significant in two or more depression variables.
From: Association between maternal depression during pregnancy and newborn DNA methylation
A. Primary outcomes: Maternal depression scores and newborn DNAm | ||||
|---|---|---|---|---|
DMRs | # CpGs | Variable | Max Effect | P-valuea |
chr18: 67069959-67070461 | 6 | EPDS Continuous | −2.60E-03 | 8.29E-10 |
BDI-II Continuous | −1.09E-03 | 6.84E-05 | ||
chr7: 155174991-155175340 | 4 | BDI-II Continuous | 1.68E-03 | 4.36E-04 |
chr8: 70378380-70378994 | 7 | BDI-II Continuous | 1.22E-03 | 5.36E-03 |
chr15: 98195808-98196247 | 4 | EPDS Continuous | −3.25E-03 | 1.19E-04 |
chr19: 18698825-18699423 | 9 | EPDS Continuous | −3.50E-03 | 1.76E-04 |
B. Secondary outcomes: Screening for maternal depression and newborn DNAm | ||||
DMRs | # CpGs | Variable | Max Effect | P-value |
chr18: 67069959-67070461 | 6 | EPDS Threshold 10 | −2.54E-02 | 2.59E-03 |
EPDS Threshold 13 | −5.40E-03 | 1.59E-02 | ||
BDI-II Threshold 20 | −2.35E-02 | 1.78E-06 | ||
chr7: 155174991-155175340 | 4 | BDI-II Threshold 14 | 6.16E-02 | 1.89E-04 |
BDI-II Threshold 20 | 3.81E-02 | 1.57E-02 | ||
chr8: 70378380-70378994 | 7 | BDI-II Threshold 20 | 3.39E-02 | 3.28E-04 |
chr15: 98195808-98196247 | 4 | EPDS Threshold 10 | −3.47E-02 | 1.19E-04 |
chr19: 18698825-18699423 | 9 | EPDS Threshold 10 | −4.23E-02 | 1.01E-04 |
