Table 2 Comparative Sanger sequencing and Luminex genotyping data for CYP2D6 variants in samples with (A) CYP2D7–2D6 hybrid haplotypes and (B) CYP2D6–2D7 hybrid haplotypes.
From: Methodology for clinical genotyping of CYP2D6 and CYP2C19
(A) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sample | Method | 31G>A | 100C>T | 124G>A | 137_138insT | 882G>C | 1660G>A | 1708delT | 1847G>A | 2550delA | 2851C>T | 2936A>C | 2989G>A | 3184G>A | 4181G>C |
EU093102 | NA | MUT | WT | WT | MUT | WT | WT | WT | WT | WT | WT | WT | Sequence not present | WT | MUT |
GQ162807 | NA | MUT | WT | WT | MUT | WT | WT | WT | WT | WT | MUT | WT | WT | WT | MUT |
1 | Luminex | MUT | WT | WT | MUT | WT | WT | WT | WT | WT | WT | WT | Low Signal | WT | MUT |
Sanger | MUT | WT | WT | MUT | WT | WT | WT | WT | WT | WT | WT | Sequence not present | WT | MUT | |
3 | Luminex | MUT | WT | WT | MUT | WT | WT | WT | WT | WT | MUT | WT | WT | WT | MUT |
Sanger | MUT | WT | WT | MUT | WT | WT | WT | WT | WT | MUT | WT | WT | WT | MUT |
(B) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Method | −1584C>G | 31G>A | 100C>T | 124G>A | 138insT | 883G>C | 1023C>T | 1659G>A | 1707delT | 1758G>T/A | 1758G>T/A | 1846G>A | 2549delA | 2850C>T | 2988G>A | 3183G>A |
Luminex | WT | WT | MUT | WT | MUT | WT | WT | WT | WT | WT | WT | MUT | WT | WT | WT | WT |
Sanger | WT | WT | MUT | WT | MUT | WT | WT | WT | WT | WT | WT | MUT | WT | WT | WT | WT |
