Fig. 2: Distribution plots of the effect sizes of the PGSoxt and PC–PGSoxt models and models from PGSs calculated from 100 random gene sets of equal size for cluster principal components and individual variables. | Translational Psychiatry

Fig. 2: Distribution plots of the effect sizes of the PGSoxt and PC–PGSoxt models and models from PGSs calculated from 100 random gene sets of equal size for cluster principal components and individual variables.

From: Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank

Fig. 2

A, B We found that a number of the statistically significant effects are specific to the oxytocin pathway and not due to the random association of the SNP in the gene set with the chosen phenotypes: schizophrenia, bipolar disorder, and type-2 diabetes mellitus. PGS polygenic score, PC1 first PGS principal component, PC2 second PGS principal component.

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