Fig. 2: Glial cell marker gene expression was altered in diagnostic and inflammatory subgroups in psychiatric disorders. | Translational Psychiatry

Fig. 2: Glial cell marker gene expression was altered in diagnostic and inflammatory subgroups in psychiatric disorders.

From: A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

Fig. 2

A–B VIM gene expression was unchanged across diagnostic groups, while pan-GFAP gene expression was reduced in schizophrenia and bipolar disorder compared to controls. C–D VIM and pan-GFAP mRNAs were unchanged across inflammatory subgroups. E IBA1 mRNA was reduced in high inflammation bipolar disorder compared to low inflammation controls. F–G HEXB and CD68 mRNAs were unchanged across inflammatory subgroups. H–I P2RY12 and P2RY13 mRNAs were reduced in high inflammation schizophrenia and bipolar disorder subgroups compared to low inflammation controls. Data are plotted relative to the mean of the control group (A–B) or low inflammation control group (100%) ± standard error of the mean (C–I). High inflammation controls are displayed as grey points but were not used in statistical analyses. BPD bipolar disorder, CTRL control, High high inflammation, Low low inflammation, SCZ schizophrenia. *p < 0.05, **p < 0.01, ***p < 0.001.

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