Fig. 2: Differentially expressed genes unique to diagnosis conditions. | Translational Psychiatry

Fig. 2: Differentially expressed genes unique to diagnosis conditions.

From: Dysregulated gene expression associated with inflammatory and translation pathways in activated monocytes from children with autism spectrum disorder

Fig. 2

A Euler plots showing the overlap among DEGs identified as upregulated or downregulated in response to LPS for each diagnosis. B Heatmap of Z-score Log2 Fold Change values for unique LPS DEGs that were significantly regulated in only AD, PDDNOS, or TD (non-overlapping regions of the Euler plots in A) with significantly enriched GO terms and KEGG pathways aligned to heatmap. See Table S6 for full lists. C Euler plots showing the overlap among DEGs identified as upregulated or downregulated in response to LTA for each diagnosis. D Heatmap of Z-score Log2 Fold Change values for unique LTA DEGs that were significantly regulated in only AD, PDDNOS or TD (non-overlapping regions of the Euler plots in C), with significantly enriched GO terms and KEGG pathways aligned to heatmap. See Table S7 for full lists. AD: autistic disorder, TD: typical developing controls, PDD/NOS: pervasive development disorder not otherwise specified, NT: no treatment, LPS: lipopolysaccharide, LTA: lipoteichoic acid.

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