Table 1 MetaXcan prediction of gene expression effects on the studied disorders for brain tissues and whole blood.

From: Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders

Gene symbol

entrezID

Gene sets

Brain tissuea

Disorder

Z-score

p value

N SNPs in model

N SNPs used

Predicted R2

ATF6B

1388

DA

 

Spinal cord

SCZ

4.7924

1.6E-06

11

5

0.1466

Whole blood

SCZ

−4.6153

3.9E-06

15

5

0.0246

ARNTL

406

DA

 

Whole blood

BIP

−3.0427

2.3E-03

16

16

0.1567

CACNA1C

775

DA

SERT

Cerebellum

CD-MA

−3.0166

2.6E-03

51

41

0.2435

SCZ

−2.4867

0.0129

51

50

0.2435

CACNA1D

776

DA

SERT

Cerebellar hemisphere

ADHD

−2.2252

0.0261

107

89

0.0988

CTNNB1

1499

DA

 

Amygdala

ADHD

−3.3246

8.9E-04

36

35

0.1692

Caudate

ADHD

−2.8011

5.1E-03

12

12

0.0789

Putamen

ADHD

−3.0637

2.2E-03

28

27

0.1740

Spinal cord

ADHD

−2.2299

0.0258

47

32

0.1377

Whole blood

ADHD

3.9041

9.5E-05

5

5

0.0392

CYP2D6

1565

 

SERT

Amygdala

CD-MA

2.5247

0.1158

15

15

0.2419

SCZ

2.3181

0.0204

15

15

0.2419

Whole blood

SCZ

−5.1188

3.1E-07

23

23

0.4488

DNM1

1759

DA

 

Cortex

ADHD

2.6308

8.5E-03

3

3

0.0502

ASD

2.7524

5.9E-03

3

3

0.0502

CD-MA

3.6516

2.6E-04

3

3

0.0502

MD

2.9630

3.0E-03

3

3

0.0502

SCZ

2.1548

0.0312

3

3

0.0502

FLOT1

10211

DA

 

Cerebellar hemisphere

SCZ

−2.2126

0.0269

79

5

0.1378

FZD3

7976

DA

 

Whole blood

SCZ

−3.0575

2.2E-03

14

14

0.0873

GCH1

2643

DA

 

Cerebellum

SCZ

−1.1404

0.0490

103

102

0.0552

GNB2

2783

 

SERT

Spinal cord

CD-MA

−2.8822

3.9E-03

31

29

0.0579

GRIN2A

2903

DA

SERT

Spinal cord

BIP

−2.6559

7.9E-03

3

3

0.2636

HTR6

3362

 

SERTb

Anterior cingulate

BIP

2.4006

0.0164

58

58

0.0968

CD-MA

2.4828

0.1303

58

49

0.0968

Whole blood

BIP

−3.1707

1.5E-03

31

30

0.2042

ITPR3

3710

DA

SERT

Caudate

CD-MA

−4.2860

1.8E-05

4

4

0.0867

Whole blood

ADHD

2.3412

0.0192

29

28

0.2384

MAPK3

5595

 

SERT

Hippocampus

SCZ

2.0050

0.0449

17

17

0.0734

Whole blood

BIP

2.8559

4.3E-03

12

12

0.2902

SCZ

5.4086

6.3E-08

12

11

0.2902

MAPK10

5602

DA

 

Anterior cingulate

BIP

2.3373

0.0194

15

15

0.1481

CD-MA

2.8561

0.0344

15

15

0.1481

Caudate

BIP

2.0394

0.0414

39

39

0.1546

CD-MA

2.1152

0.0344

39

32

0.1546

Cortex

BIP

2.6829

7.3E-03

28

28

0.0880

CD-MA

2.6987

7.0E-03

28

22

0.0880

Nucleus accumbens

BIP

2.1524

0.0314

35

35

0.1187

CD-MA

2.3767

0.0175

35

33

0.1187

PPP1CB

5500

DA

 

Whole blood

SCZ

3.7165

2.0E-04

23

23

0.1395

PPP2R3C

55012

DA

 

Whole blood

SCZ

4.9201

8.6E-07

20

19

0.4025

PRMT5

10419

DA

 

Whole blood

SCZ

−2.8138

4.9E-03

23

22

0.2572

  1. In bold: Significant p values overcoming the Bonferroni correction for multiple testing.
  2. ADHD Attention-deficit/hyperactivity disorder, ASD Autism spectrum disorder, BIP Bipolar disorderm, MD Major depression, SCZ Schizophrenia, CD-MA Cross-disorder meta-analysis.
  3. aPrediction models were only available for some tissues and genes; Z-score: Number of standard deviations change in gene expression; p value: Significance of the association between predicted expression levels and the disorder; N SNPs in model: Number of SNPs used in the training of prediction models for each gene; N SNPs used: Number of SNPs used from the corresponding GWAS summary statistics; Predicted R2: Correlation between the predicted and observed gene expression during prediction model training; DA: Wide dopaminergic gene set; SERT: Wide serotonergic gene set.
  4. bGene present in SERT core gene set.
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