Fig. 4: Compound context-cue fear responses. | Translational Psychiatry

Fig. 4: Compound context-cue fear responses.

From: Serotonin 5-HT2C receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning

Fig. 4

a Schematic drawing of each of the three phases of the compound context-cue condition lick suppression task. b Contextual conditioned lick suppression performance in WT mice (Compound WT Group; N = 7) compared to KO mice (Compound KO Group; N = 7) tested from Day 7 to Day 10 in the same context (Context A) where they received the fear conditioning session. Two-way analysis of variance (ANOVA) for repeated measures. Data are represented as means and error bars represent ±SEM. c Cued conditioned lick suppression performance in WT mice (Compound WT Group; N = 7) compared to KO mice (Compound KO Group; N = 7) during the first tone delivery at Day 7 in a different context (Context B) from that of the conditioning phase (Context A). Two-tailed t-test for independent samples. Black full lines and dashed black lines of violin plots represent medians and quartiles (first and third) respectively. d–g Percentage probability of survival rate between WT (Compound WT Group; N = 7) and KO mice (Compound KO Group; N = 7) tested from Day 7 to Day 10. Log-rank (Mantel-Cox) tests.

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