Fig. 2: Multimodal HPA axis response after CSDS discriminates stress phenotypes.
From: Stress vulnerability shapes disruption of motor cortical neuroplasticity
a Plasma corticosterone (CORT) levels were increased 24 h post CSDS (F2,42 = 5.954, P = 0.005, one-way ANOVA with Holm-Sidak’s post-hoc test); ctrl n = 19, resilient n = 12, susceptible n = 14. b Post-stress plasma CORT changed significantly relative to baseline (dashed line) as tested by one sample t-tests in controls (t13 = 2.365, P = 0.034) and susceptible mice (t8 = 3.063, P = 0.016) but not in resilient ones (t9 = 0.843, P = 0.421); ctrl n = 14, resilient n = 10, susceptible n = 9. c Fecal CORT reflects cumulative release 24 h after CSDS and was significantly different between stressed phenotypes and stressed vs. control mice (F2,41 = 7.897, P = 0.001, one-way ANOVA with Holm-Sidak’s post-hoc test); ctrl n = 20, resilient n = 12, susceptible n = 12 mice. d Adrenal gland weight measured 36 days post CSDS was significantly higher in the susceptible mice compared to controls and resilient mice (F2,41 = 4.580, P = 0.016, one-way ANOVA with Holm-Sidak’s post-hoc test); ctrl n = 19, resilient n = 12, susceptible n = 14 mice. *P < 0.05, **P < 0.01, ***P < 0.001. Results are shown as mean ± SEM.
