Fig. 3: Metabolite levels in the vHip of rats exposed to CMS. | Translational Psychiatry

Fig. 3: Metabolite levels in the vHip of rats exposed to CMS.

From: Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress

Fig. 3: Metabolite levels in the vHip of rats exposed to CMS.

A Heatmap representing all analyzed metabolites by targeted LC-MS/MS metabolomics. Metabolites highlighted in red were statistically significant with a FDR < 0.15; B relative levels of several mono-, di, and triphosphate nucleotides (NTPs), C relative levels of 1C cycle intermediates, D relative levels of glycolysis metabolites, E relative levels of TCA cycle intermediates, F relative levels of glutamine and glutamate, G relative levels of acylcarnitines, H fold change of ATP energy charge and NAD+/NADH ratio, panel I: relative levels of urea cycle intermediates in control (no stress) or stressed (CMS-vul/CMS-res) animals. B–G, I: the data are the mean ± SD. *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001 vs no stress; #FDR < 0.05, ##FDR < 0.01 vs CMS-vul (one-way ANOVA, Fisher’s PLSD). H mean ± SEM. **FDR < 0.01, **FDR < 0.001 vs no stress; ##FDR < 0.01 vs CMS-vul (one-way ANOVA, Fisher’s PLSD).

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