Fig. 2: Association between symptom severity while on clozapine and polygenic risk scores for schizophrenia. | Translational Psychiatry

Fig. 2: Association between symptom severity while on clozapine and polygenic risk scores for schizophrenia.

From: Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Fig. 2: Association between symptom severity while on clozapine and polygenic risk scores for schizophrenia.The alternative text for this image may have been generated using AI.

A, B. Bar plot illustrating the explained variance for the association of schizophrenia-PRS with binary outcome at several pt, adjusted for sex, age, and 10 PCs. pt are displayed on the X-axis, where the number of included SNPs increases with more lenient pt. Δ Explained variance represents the Nagelkerke R2 (shown as %). The red dots represent the significance of the association results (-Log 10 p value). The dashed line represents a nominal significance-level of p < 0.05 (A). Individual risk prediction: higher schizophrenia-PRS was associated with higher positive predictive value for low symptom severity. Whiskers represent confidence intervals (±1.96 × standard error) around the central positive predictive value estimate (B).

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