Fig. 1: Ketamine induces IGF-1 release in the mPFC. | Translational Psychiatry

Fig. 1: Ketamine induces IGF-1 release in the mPFC.

From: IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine

Fig. 1

a IGF-1 levels in extracellular fluid in the mPFC after i.p. injection of either saline (n = 13) or ketamine (3 mg/kg, n = 6; 10 mg/kg, n = 13; 30 mg/kg, n = 6; treatment × time interaction, F21,238 = 2.796, p < 0.0001). *p < 0.05, **p < 0.01, ***p < 0.001, saline vs. ketamine 10 mg/kg; #p < 0.05, ##p < 0.01, saline vs. ketamine 30 mg/kg (two-way repeated measures ANOVA followed by Holm–Sidak’s post hoc test). b Serum IGF-1 levels 3 h after i.p. injection of either saline (n = 7) or ketamine (10 mg/kg; n = 7; t12 = 0.219, p = 0.8304, two-tailed t-test). Data are expressed as means ± SEM.

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