Table 3 Specific differentially methylated CpG sites.

From: Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study

Group 1

Group 2

Gene

Location

Probe

Log2 fold change

Mean (SD)

Unadjusted p value

Adjusted p value

Regulatory feature

Whole study cohort

         

 PND-High ext

PND-Low ext

Unknown

chr3, 142849987

cg05153152

−0.60

3.06 (0.37)

3.55 (0.57)

4.77E−08

0.038

Unkown

Female offspring

         

 HC-Low ext

PND-Low ext

Unknown

chr6, 67659438

cg01533057

−1.10

4.14 (0.41)

5.00 (0.42)

4.15E−08

0.034

Unkown

Male offspring

         

 PND-High int

PND-Low int

Nudix Hydrolase 15 (NUDT15)

chr13, 48610331

cg07027016

−0.72

2.95 (0.30)

3.5 (0.31)

1.36E−08

0.011

Unkown

 HC-High ext

HC-Low ext

Tata-Box Binding protein (TAF10) and Tripeptidyl Peptidase 1 (TPP1)

chr11 6634101

cg00640240

0.45

−4.48 (0.32)

−4.86 (0.28)

2.65E−08

0.022

Promoter associated

  1. Location: chr chromosome and genomic position. Groups are based on self-reported prenatal depressive symptoms (PND) or healthy controls (HC) and parental reported child high or low internalizing (int) and externalizing (ext) behavior scores. Group difference in DNA methylation in specific CpGs are presented as log2 fold change (log2 (M value group 1/ M value group 2)) between the groups, meaning that a negative log2 fold changes means lower DNA methylation in group 1. Mean standard deviation (SD) = mean DNA methylation and SD for group 1, group 2.
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