Fig. 6: ELA does not substantially alter the neuronal response to heroin in NAc-projecting cells.
From: Enduring disruption of reward and stress circuit activities by early-life adversity in male rats
A Diagram of NAc CTb injection placements and example of cell appearance. Black arrow = Fos+, clear arrow = CTb+; white arrow = Fos+CTb+ cell. B Percentage of total CTb-labeled cells that are also Fos+ in all animals collapsed across opioid exposure conditions. There was no effect of ELA on the activation of NAc-projecting cells in BLA, PVT, or PFC. C Percentage of total CTb-labeled cells that are also Fos+ in all animals separated by opioid history. # opioid-naive vs. opioid-experienced P = 0.05. experienced n = 5 CTL/6 ELA; naïve n = 4 CTL (3 CTL for PFC)/7 ELA.
