Table 2 Results of meta-analyses included in the umbrella review.

From: Genetics of autism spectrum disorder: an umbrella review of systematic reviews and meta-analyses

Studies

Genes

SNPs

Number of studies

Allelic model

Dominant model

Heterozygote model

Homozygote model

Recessive model

    

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

Uddin et al. [44]

CNTNAP2

rs2710102

5

0.85 (0.73–0.98)

0.88 (0.68–1.14)

0.96 (0.74–1.26)

0.67 (0.47–0.95)

0.72 (0.56–0.91)

Wang et al. [43]

CNTNAP2

rs2710102

7

1.00 (0.84–1.18)

–

–

–

0.98 (0.77–1.07)

Werling et al. [41]

CNTNAP2

rs2710102

5

1.03 (0.98–1.08)

–

–

–

–

Zhang et al. [42]

CNTNAP2

rs2710102

7

0.99 (0.94–1.03)

–

–

–

–

Uddin et al. [44]

CNTNAP2

rs7794745

8

1.21 (0.97–1.51)

1.30 (1.11–1.52)

1.28 (1.08–1.50)

1.49 (0.78–2.86)

1.30 (0.69–2.44)

Werling et al. [41]

CNTNAP2

rs7794745

6

1.02 (0.99–1.05)

–

–

–

–

Zhanget al. [42]

CNTNAP2

rs7794745

8

1.00 (0.90–1.12)

–

–

–

–

Yang et al. [39]

COMT

rs4680

4

0.97 (0.84–1.13)

–

–

–

–

Mahdavi et al. [51]

GABRB3

rs1426217

3

1.13 (0.64–2.00)

–

–

–

–

Noroozi et al. [52]

GABRB3

rs20317

3

0.92 (0.78–1.08)

0.97 (0.65–1.44)

0.86 (0.50–1.47)

1.07 (0.74–1.55)

1.09 (0.82–1.46)

Mahdavi et al. [51]

GABRB3

rs2081648

4

0.84 (0.41–1.72)

–

–

–

–

Noroozi et al. [52]

GABRB3

rs4906902

5

1.04 (0.92–1.17)

0.98 (0.83–1.16)

0.96 (0.82–1.13)

0.94 (0.71–1.24)

0.94 (0.72–1.23)

Li et al. [33]

MTHFR

A1298C

9

1.17 (0.91–1.50)

1.19 (0.87–1.64)

1.11 (0.82–1.50)

1.31 (0.82–2.09)

1.17 (0.76–1.78)

Pu et al. [29]

MTHFR

A1298C

5

0.86 (0.68–1.08)

0.93 (0.70–1.23)

0.98 (0.68–1.43)

0.79 (0.59–1.07)

0.73 (0.56–0.97)

Razi et al. [32]

MTHFR

A1298C

8

1.18 (0.86–1.63)

1.17 (0.78–1.75)

1.19 (0.80–1.76)

1.00 (0.61–1.64)

0.77 (0.40–1.49)

Sadeghiyeh et al. [31]

MTHFR

A1298C

7

0.94 (0.77–1.16)

0.98 (0.74–1.30)

1.04 (0.75–1.44)

0.92 (0.69–1.21)

0.83 (0.64–1.08)

Li et al. [33]

MTHFR

C677T

15

1.63 (1.30–2.05)

1.82 (1.39–2.37)

1.66 (1.31–2.11)

2.03 (1.33–3.09)

1.59 (1.14–2.22)

Li et al. [34]

MTHFR

C677T

6

1.88 (1.15–3.08)

1.96 (1.18–3.25)

1.68 (1.11–2.55)

2.31 (1.23–4.34)

1.93 (1.09–3.40)

Pu et al. [29]

MTHFR

C677T

8

1.42 (1.09–1.85)

1.56 (1.12–2.18)

1.48 (1.09–2.00)

1.86 (1.08–3.20)

1.56 (1.12–2.18)

Rai [30]

MTHFR

C677T

13

1.48 (1.18–1.86)

1.70 (0.96–2.90)

1.60 (1.20–2.10)

1.84 (1.12–3.02)

1.50 (1.00–2.20)

Razi [32]

MTHFR

C677T

17

1.37 (1.08–1.74)

1.47 (1.13–1.93)

1.45 (1.13–1.85)

1.40 (0.87–2.27)

1.14 (0.79–1.64)

Sadeghiyeh et al. [31]

MTHFR

C677T

18

1.64 (1.30–2.08)

1.60 (1.12–2.30)

1.51 (1.09–2.10)

1.99 (1.29–3.06)

1.48 (1.06–2.08)

Wang and Wu [35]

MTHFR

C677T

14

1.63 (1.20–2.22)

1.75 (1.28–2.38)

1.56 (1.24–1.98)

1.60 (1.06–2.41)

1.33 (0.93–1.92)

Zhang [36]

MTHFR

C677T

16

1.80 (1.30–2.48)

1.96 (1.40–2.74)

1.77 (1.34–2.33)

1.80 (1.16–2.78)

1.42 (0.98–2.07)

LoParo and Waldman [45]

OXTR

rs1042778

6

0.97 (0.87–1.09)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs11706648

4

1.02 (0.89–1.18)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs2254298

6

1.15 (0.93–1.43)

–

–

–

–

Zhou [47]

OXTR

rs2254298

5

1.06 (0.81–1.38)

1.06 (0.85–1.31)

1.03 (0.82–1.29)

1.26 (0.79–2.02)

1.25 (0.79–1.97)

LoParo and Waldman [45]

OXTR

rs2268490

4

1.13 (0.93–1.34)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs2268491

6

1.19 (1.05–1.36)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs2268493

4

0.98 (0.71–1.33)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs2268495

6

0.97 (0.78–1.21)

–

–

–

–

Zhou [47]

OXTR

rs2301261

3

1.00 (0.62–1.63)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs237885

8

0.96 (0.85–1.08)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs237887

6

0.88 (0.79–0.98)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs237888

4

1.17 (0.92–1.50)

–

–

–

–

Kranz [46]

OXTR

rs237889

4

1.12 (1.01–1.24)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs237894

4

1.03 (0.84–1.27)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs237895

4

1.21 (0.98–1.48)

–

–

–

–

Kranz et al. [46]

OXTR

rs237897

4

1.05 (0.88–1.25)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs4684302

4

0.87 (0.64–1.23)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs4686301

4

1.15 (0.92–1.43)

–

–

–

–

LoParo and Waldman [45]

OXTR

rs53576

5

0.91 (0.76–1.09)

–

–

–

–

Zhou [47]

OXTR

rs53576

4

0.91 (0.80–1.02)

0.84 (0.59–1.19)

0.79 (0.55–1.13)

0.91 (0.64–1.29)

0.93 (0.54–1.60)

LoParo and Waldman [45]

OXTR

rs7632287

4

1.44 (1.23–1.68)

–

–

–

–

Chen et al. [49]

RELN

rs2229864

4

1.01 (0.83–1.24)

1.08 (0.84–1.38)

–

–

–

Hernández-García et al. [50]

RELN

rs2229864

4

–

–

–

–

0.75 (0.48–1.16)

Chen et al. [49]

RELN

rs362691

5

0.88 (0.70–1.10)

0.87 (0.68–1.11)

–

–

–

Hernández-García et al. [50]

RELN

rs362691

6

–

–

–

–

1.03 (0.77–1.38)

Wang et al. [48]

RELN

rs362691

3

0.80 (0.44–1.46)

–

–

–

–

Wang et al. [48]

RELN

rs362691

5

0.82 (0.61–1.10)

–

–

–

–

Chen et al. [49]

RELN

rs607755

3

0.73 (0.53–1.02)

0.76 (0.48–1.20)

–

–

–

Chen et al. [49]

RELN

rs736707

5

0.90 (0.67–1.20)

0.87 (0.57–1.33)

–

–

–

Hernández-García et al. [50]

RELN

rs736707

6

–

–

–

–

1.02 (0.76–1.37)

Wang et al. [48]

RELN

rs736707

6

1.11 (0.80–1.54)

–

–

–

–

Aoki and Cortese [53]

SLC25A12

rs2056202

11

1.21 (1.04–1.41)

–

–

–

–

Aoki and Cortese [53]

SLC25A12

rs2056202

5

1.07 (0.85–1.34)

–

–

–

–

Aoki and Cortese [53]

SLC25A12

rs2056202

6

1.27 (1.04–1.54)

–

–

–

–

Liu et al. [54]

SLC25A12

rs2056202

8

0.81 (0.71–0.92)

–

–

–

–

Liu et al. [54]

SLC25A12

rs2056202

5

0.78 (0.67–0.90)

–

–

–

–

Liu et al. [54]

SLC25A12

rs2056202

4

0.99 (0.80–1.22)

–

–

–

–

Aoki and Cortese [53]

SLC25A12

rs2292813

10

1.19 (1.05–1.35)

–

–

–

–

Aoki and Cortese [53]

SLC25A12

rs2292813

3

0.90 (0.59–1.36)

–

–

–

–

Aoki and Cortese [53]

SLC25A12

rs2292813

7

1.22 (1.08–1.38)

–

–

–

–

Liu et al. [54]

SLC25A12

rs2292813

7

0.75 (0.65–0.87)

–

–

–

–

Liu et al. [54]

SLC25A12

rs2292813

6

0.75 (0.63–0.88)

–

–

–

–

Huang et al. [37]

SLC6A4

5-HTTLPR

13

1.03 (0.84–1.27)

–

–

–

–

Huang et al. [37]

SLC6A4

5-HTTLPR

14

1.05 (0.88–1.25)

–

–

–

–

Mo et al. [38]

SLC6A4

5-HTTLPR

6

1.19 (0.83–1.72)

–

–

–

–

Mo et al. [38]

SLC6A4

5-HTTLPR

19

1.07 (0.92–1.25)

–

–

–

–

Mo et al. [38]

SLC6A4

5-HTTLPR

25

1.10 (0.95–1.26)

–

–

–

–

Wang et al. [40]

SLC6A4

5-HTTLPR

11

1.13 (0.95–1.34)

1.11 (0.91–1.35)

–

1.20 (0.82–1.78)

1.08 (0.73–1.58)

Yang et al. [39]

SLC6A4

5-HTTLPR

18

1.04 (0.89–1.21)

–

–

–

–

Yang et al. [39]

SLC6A4

5-HTTLPR

6

1.19 (0.86–1.65)

–

–

–

–

Huang et al. [37]

SLC6A4

STin2 VNTR

8

1.13 (0.82–1.56)

–

–

–

–

Sun [55]

VDR

rs11568820

4

1.05 (0.89–1.23)

1.03 (0.83–1.27)

0.99 (0.79–1.24)

1.12 (0.78–1.60)

1.15 (0.82–1.62)

Yang and Wu [56]

VDR

rs11568820

3

1.12 (0.92–1.37)

1.06 (0.67–1.66)

0.99 (0.60–1.64)

1.19 (0.78–1.81)

1.21 (0.82–1.80)

Sun and Wu [55]

VDR

rs1544410

5

1.07 (0.92–1.24)

1.04 (0.84–1.30)

1.00 (0.79–1.25)

1.16 (0.84–1.61)

1.17 (0.89–1.52)

Yang and Wu [56]

VDR

rs1544410

5

1.07 (0.92–1.24)

1.02 (0.82–1.28)

0.96 (0.76–1.21)

1.20 (0.86–1.67)

1.20 (0.92–1.58)

Sun [55]

VDR

rs2228570

7

1.09 (0.96–1.24)

1.01 (0.84–1.21)

0.93 (0.77–1.13)

1.39 (1.04–1.87)

1.36 (1.05–1.75)

Yang and Wu [56]

VDR

rs2228570

4

0.95 (0.80–1.12)

0.86 (0.67–1.10)

0.81 (0.63–1.05)

0.99 (0.69–1.44)

1.06 (0.79–1.43)

Sun [55]

VDR

rs731236

6

1.30 (1.12–1.49)

1.30 (1.08–1.57)

1.20 (0.86–1.67)

1.74 (1.26–2.41)

1.61 (1.19–2.19)

Yang and Wu [56]

VDR

rs731236

3

1.33 (1.09–1.61)

1.26 (0.79–2.01)

1.10 (0.60–2.01)

2.09 (1.34–3.25)

1.96 (1.30–2.96)

Sun [55]

VDR

rs7975232

3

0.82 (0.68–0.99)

0.74 (0.54–1.02)

0.76 (0.54–1.07)

0.53 (0.22–1.28)

0.74 (0.40–1.34)

Yang and Wu [56]

VDR

rs7975232

3

0.82 (0.68–0.99)

0.74 (0.54–1.02)

0.76 (0.54–1.07)

0.53 (0.22–1.28)

0.74 (0.40–1.34)

  1. – no data/data not complete.
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