Table 3 Information on meta-analyses included for further analysis.
From: Genetics of autism spectrum disorder: an umbrella review of systematic reviews and meta-analyses
Studies | Genes | SNPs | Number of studies | Cases | Controls | Â | ||||
|---|---|---|---|---|---|---|---|---|---|---|
n | A/B | AA/AB/BB | n | A/B | AA/AB/BB | P_value of HWE | ||||
Uddin et al. [44] | CNTNAP2 | rs2710102 | 5 | 684 | 751/617 | 189/373/122 | 12563 | 12204/12922 | 2964/6276/3323 | 0.995 |
| Â | Â | rs7794745 | 8 | 1206 | 936/1476 | 158/620/428 | 13191 | 9404/16978 | 1682/6040/5469 | 0.821 |
Yang et al. [39] | COMT | rs4680 | 4 | 814 | 779/849 | – | 741 | 690/778 | – | … |
Noroozi et al. [52] | GABRB3 | rs20317 | 3 | 636 | 493/779 | 113/267/256 | 787 | 692/882 | 185/322/280 | <0.001 |
| Â | Â | rs4906902 | 5 | 1297 | 729/1865 | 118/493/686 | 1423 | 794/2052 | 125/544/754 | 0.061 |
Li et al. [33] | MTHFR | A1298C | 9 | 1961 | 1182/2740 | 225/732/1004 | 2034 | 1186/2882 | 209/768/1057 | <0.001 |
Zhang et al. [36] | MTHFR | C677T | 16 | 2147 | 1559/2735 | 290/979/878 | 2253 | 1387/3119 | 259/869/1125 | <0.001 |
Zhou [47] | OXTR | rs2254298 | 5 | 1181 | 475/1863 | – | 1790 | 672/2884 | – | … |
|  |  | rs2301261 | 3 | 474 | 93/855 | – | 951 | 179/1723 | – | … |
|  |  | rs53576 | 4 | 1081 | 871/1263 | – | 1558 | 1220/1864 | – | … |
Chen et al. [49] | RELN | rs607755 | 3 | 298 | 252/344 | 52/148/98 | 270 | 209/331 | 44/121/105 | 0.362 |
Hernández-GarcÃa et al. [50] | RELN | rs2229864 | 4 | 646 | 969/323 | 363/243/40 | 774 | 1219/329 | 486/247/41 | 0.195 |
| Â | Â | rs362691 | 6 | 780 | 941/619 | 398/145/237 | 882 | 1014/750 | 419/176/287 | <0.001 |
| Â | Â | rs736707 | 6 | 868 | 814/922 | 201/412/255 | 1093 | 995/1191 | 237/521/335 | 0.198 |
Wang et al. [40] | SLC6A4 | 5-HTTLPR | 11 | 930 | 884/922 | 243/398/262 | 1234 | 1045/1373 | 282/481/446 | <0.001 |
Sun [55] | VDR | rs11568820 | 4 | 844 | 478/1210 | 88/302/454 | 689 | 385/993 | 68/249/372 | 0.007 |
| Â | Â | rs1544410 | 5 | 993 | 702/1284 | 161/380/452 | 904 | 645/1163 | 138/369/397 | <0.001 |
| Â | Â | rs2228570 | 7 | 1107 | 858/1356 | 195/468/444 | 1110 | 826/1394 | 163/500/447 | 0.230 |
| Â | Â | rs731236 | 6 | 1088 | 664/1512 | 127/410/551 | 1020 | 519/1521 | 76/367/577 | 0.099 |
| Â | Â | rs7975232 | 3 | 430 | 409/451 | 87/235/108 | 491 | 506/476 | 116/274/101 | 0.009 |
