Fig. 2: The BGM analysis of BDNF found 23 pairs of coevolving sites out of 261 total sites to be statistically significant (with a posterior probability threshold of 0.5). | Translational Psychiatry

Fig. 2: The BGM analysis of BDNF found 23 pairs of coevolving sites out of 261 total sites to be statistically significant (with a posterior probability threshold of 0.5).

From: The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease?

Fig. 2: The BGM analysis of BDNF found 23 pairs of coevolving sites out of 261 total sites to be statistically significant (with a posterior probability threshold of 0.5).

Here, we plot only the statistically significant coevolving pairs. The number of shared substitutions between pairs of coevolving sites is visualized by the size of the circle, with larger circles indicating more shared substitutions. Poster probability of the interaction (coevolving pair) corresponds to the color blue, with dark blue indicating higher values. Individual BDNF sites are mapped on both the X and Y axis so that readers can view which sites are coevolving with another. Once more, note that the coevolution tends to be focally constrained to the broader BDNF prodomain region at a topological level, which is once more consistent with the idea that the NGF domain (site >144; see Fig. 3) is highly conserved and probably deleteriously impacted by variation. However, we did discover four sites of coevolution in the NGF domain (basically, the mature BDNF protein) that are evolving with early prodomain sites. This highlights that both proximal and distal sites in BDNF can, and indeed are, evolving together over time.

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