Table 2 The BGM analysis of BDNF found 23 pairs of coevolving sites out of 261 total sites to be statistically significant (with a posterior probability threshold of 0.5).

From: The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease?

#

Site 1

Site 2

P [Site 1 –> Site 2]

P [Site 2 –> Site 1]

P [Site 1 < –> Site 2]

Site 1 subs

Site 2 subs

Shared subs

1

5

67

0.52

0.32

0.84

1

1

1

2

25

49

0.022

0.67

0.69

8

6

3

3

27

109

0.12

0.45

0.57

2

1

1

4

30

119

0.2

0.56

0.75

6

12

4

5

33

119

0.12

0.72

0.84

3

12

3

6

39

103

0.22

0.58

0.8

8

4

3

7

49

85

0.48

0.049

0.53

6

3

2

8

49

86

0.36

0.55

0.91

6

5

3

9

50

69

0.31

0.27

0.58

1

2

1

10

62

64

0.25

0.27

0.52

1

1

1

11

70

74

0.17

0.38

0.55

7

14

4

12

70

95

0.59

0.26

0.85

7

21

5

13

74

94

0.034

0.64

0.68

14

7

4

14

78

90

0.46

0.38

0.84

1

1

1

15

81

93

0.27

0.31

0.58

1

1

1

16

81

98

0.27

0.33

0.61

1

1

1

17

82

91

0.045

0.92

0.96

15

29

9

18

89

184

0.24

0.5

0.74

2

6

2

19

91

119

0.22

0.67

0.89

29

12

8

20

93

98

0.31

0.3

0.61

1

1

1

21

94

155

0.28

0.29

0.57

7

2

2

22

103

233

0.4

0.13

0.53

4

3

2

23

135

154

0.4

0.43

0.82

1

1

1

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