Table 3 Tabulation of species included in our analysis, comprising NCBI ortholog gene IDs, symbols, mammalian species, common name, and RefSeq accessions.

From: The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease?

Gene ID

Gene symbol

Description

Scientific name

Common name

RefSeq transcript accessions

RefSeq protein accessions

627

BDNF

brain-derived neurotrophic factor

Homo sapiens

human

NM_001709.5

NP_001700.2

12064

Bdnf

brain-derived neurotrophic factor

Mus musculus

house mouse

NM_001048142.1

NP_001041607.1

24225

Bdnf

brain-derived neurotrophic factor

Rattus norvegicus

Norway rat

NM_001270630.1

NP_001257559.1

397495

BDNF

brain-derived neurotrophic factor

Sus scrofa

pig

XM_005654684.3

XP_005654741.1

403461

BDNF

brain-derived neurotrophic factor

Canis lupus familiaris

dog

XM_038429434.1

XP_038285362.1

493690

BDNF

brain-derived neurotrophic factor

Felis catus

domestic cat

NM_001009828.1

NP_001009828.1

503511

BDNF

brain-derived neurotrophic factor

Pan troglodytes

chimpanzee

NM_001012441.1

NP_001012443.1

554233

BDNF

brain-derived neurotrophic factor

Monodelphis domestica

gray short-tailed opossum

XM_007497196.2

XP_007497258.1

617701

BDNF

brain-derived neurotrophic factor

Bos taurus

cattle

XM_005216334.4

XP_005216391.1

701245

BDNF

brain-derived neurotrophic factor

Macaca mulatta

Rhesus monkey

XM_015114598.2

XP_014970084.1

100009689

BDNF

brain-derived neurotrophic factor

Equus caballus

horse

NM_001081787.1

NP_001075256.1

100081142

BDNF

brain-derived neurotrophic factor

Ornithorhynchus anatinus

platypus

XM_029059317.2

XP_028915150.1

100356949

BDNF

brain-derived neurotrophic factor

Oryctolagus cuniculus

rabbit

XM_017345633.1

XP_017201122.1

100409412

BDNF

brain-derived neurotrophic factor

Callithrix jacchus

white-tufted-ear marmoset

XM_009007854.3

XP_009006102.1

100447350

BDNF

brain-derived neurotrophic factor

Pongo abelii

Sumatran orangutan

XM_002821931.2

XP_002821977.1

100467162

BDNF

brain-derived neurotrophic factor

Ailuropoda melanoleuca

giant panda

XM_011226480.3

XP_011224782.2

100594402

BDNF

brain-derived neurotrophic factor

Nomascus leucogenys

northern white-cheeked gibbon

XM_003254347.2

XP_003254395.1

100667885

BDNF

brain-derived neurotrophic factor

Loxodonta africana

African savanna elephant

XM_023550772.1

XP_023406540.1

100730257

Bdnf

brain-derived neurotrophic factor

Cavia porcellus

domestic guinea pig

XM_013147262.2

XP_013002716.1

100768664

Bdnf

brain-derived neurotrophic factor

Cricetulus griseus

Chinese hamster

XM_007653166.4

XP_007651356.1

100934810

BDNF

brain-derived neurotrophic factor

Sarcophilus harrisii

Tasmanian devil

XM_031944159.1

XP_031800019.1

100958946

BDNF

brain-derived neurotrophic factor

Otolemur garnettii

small-eared galago

XM_012814047.1

XP_012669501.1

100983866

BDNF

brain-derived neurotrophic factor

Pan paniscus

pygmy chimpanzee

XM_034932318.1

XP_034788209.1

101007866

BDNF

brain-derived neurotrophic factor

Papio anubis

olive baboon

XM_017948537.3

XP_017804026.1

101037414

BDNF

brain-derived neurotrophic factor

Saimiri boliviensis

Bolivian squirrel monkey

XM_003919940.3

XP_003919989.2

101117275

BDNF

brain-derived neurotrophic factor

Ovis aries

sheep

XM_012096129.4

XP_011951519.2

101134399

BDNF

brain-derived neurotrophic factor

Gorilla gorilla

western gorilla

XM_004050851.2

XP_004050899.1

101281702

BDNF

brain-derived neurotrophic factor

Orcinus orca

killer whale

XM_004263941.3

XP_004263989.1

101338565

BDNF

brain-derived neurotrophic factor

Tursiops truncatus

common bottlenose dolphin

XM_019947883.2

XP_019803442.1

101350169

LOC101350169

brain-derived neurotrophic factor

Trichechus manatus latirostris

Florida manatee

XM_004369733.1

XP_004369790.1

101372507

BDNF

brain-derived neurotrophic factor

Odobenus rosmarus divergens

Pacific walrus

XM_004408653.1

XP_004408710.1

101398458

LOC101398458

brain-derived neurotrophic factor

Ceratotherium simum simum

southern white rhinoceros

XM_004418542.2

XP_004418599.1

101428552

BDNF

brain-derived neurotrophic factor

Dasypus novemcinctus

nine-banded armadillo

XM_012523604.2

XP_012379058.1

101528222

BDNF

brain-derived neurotrophic factor

Ochotona princeps

American pika

XM_004585440.1

XP_004585497.1

101553155

BDNF

brain-derived neurotrophic factor

Sorex araneus

European shrew

XM_004607860.1

XP_004607917.1

101566518

Bdnf

brain-derived neurotrophic factor

Octodon degus

degu

XM_004644113.2

XP_004644170.1

101600646

Bdnf

brain-derived neurotrophic factor

Jaculus jaculus

lesser Egyptian jerboa

XM_004660846.2

XP_004660903.1

101632951

BDNF

brain-derived neurotrophic factor

Condylura cristata

star-nosed mole

XM_004682964.2

XP_004683021.1

101643198

BDNF

brain-derived neurotrophic factor

Echinops telfairi

small Madagascar hedgehog

XM_004708253.2

XP_004708310.1

101687038

BDNF

brain-derived neurotrophic factor

Mustela putorius furo

domestic ferret

XM_004755891.2

XP_004755948.1

101704465

Bdnf

brain-derived neurotrophic factor

Heterocephalus glaber

naked mole-rat

XM_004851581.3

XP_004851638.1

101837384

Bdnf

brain-derived neurotrophic factor

Mesocricetus auratus

golden hamster

XM_005064810.4

XP_005064867.1

101954451

Bdnf

brain-derived neurotrophic factor

Ictidomys tridecemlineatus

thirteen-lined ground squirrel

XM_040284582.1

XP_040140516.1

101993181

Bdnf

brain-derived neurotrophic factor

Microtus ochrogaster

prairie vole

XM_005364052.2

XP_005364109.1

102016703

Bdnf

brain-derived neurotrophic factor

Chinchilla lanigera

long-tailed chinchilla

XM_005401751.2

XP_005401808.1

102126294

BDNF

brain-derived neurotrophic factor

Macaca fascicularis

crab-eating macaque

XM_005578346.2

XP_005578403.1

102180782

BDNF

brain-derived neurotrophic factor

Capra hircus

goat

XM_005690025.2

XP_005690082.2

102247090

BDNF

brain-derived neurotrophic factor

Myotis brandtii

Brandt’s bat

XM_014545223.1

XP_014400709.1

102279714

BDNF

brain-derived neurotrophic factor

Bos mutus

wild yak

XM_005890667.2

XP_005890729.1

102395046

BDNF

brain-derived neurotrophic factor

Bubalus bubalis

water buffalo

XM_006068006.2

XP_006068068.1

102440705

BDNF

brain-derived neurotrophic factor

Myotis lucifugus

little brown bat

XM_023756374.1

XP_023612142.1

102475289

BDNF

brain-derived neurotrophic factor

Tupaia chinensis

Chinese tree shrew

XM_014591303.2

XP_014446789.1

102511705

BDNF

brain-derived neurotrophic factor

Camelus ferus

Wild Bactrian camel

XM_006195083.3

XP_006195145.1

102532564

BDNF

brain-derived neurotrophic factor

Vicugna pacos

alpaca

XM_031681074.1

XP_031536934.1

102730927

BDNF

brain-derived neurotrophic factor

Leptonychotes weddellii

Weddell seal

XM_031025064.1

XP_030880924.1

102754946

BDNF

brain-derived neurotrophic factor

Myotis davidii

 

XM_006753948.2

XP_006754011.1

102839210

BDNF

brain-derived neurotrophic factor

Chrysochloris asiatica

Cape golden mole

XM_006864851.1

XP_006864913.1

102870215

BDNF

brain-derived neurotrophic factor

Elephantulus edwardii

Cape elephant shrew

XM_006883713.1

XP_006883775.1

102896087

BDNF

brain-derived neurotrophic factor

Pteropus alecto

black flying fox

XM_006907988.2

XP_006908050.1

102911929

Bdnf

brain-derived neurotrophic factor

Peromyscus maniculatus bairdii

prairie deer mouse

XM_006980818.2

XP_006980880.1

102958723

BDNF

brain-derived neurotrophic factor

Panthera tigris altaica

Amur tiger

XM_015544869.1

XP_015400355.1

102977934

BDNF

brain-derived neurotrophic factor

Physeter catodon

sperm whale

XM_028501134.1

XP_028356935.1

103017938

BDNF

brain-derived neurotrophic factor

Balaenoptera acutorostrata scammoni

XM_007180991.1

XP_007181053.1

103085069

BDNF

brain-derived neurotrophic factor

Lipotes vexillifer

Yangtze River dolphin

XM_007461679.1

XP_007461741.1

103126099

BDNF

brain-derived neurotrophic factor

Erinaceus europaeus

western European hedgehog

XM_016194241.1

XP_016049727.1

103206496

BDNF

brain-derived neurotrophic factor

Orycteropus afer afer

 

XM_007951952.1

XP_007950143.1

103238537

BDNF

brain-derived neurotrophic factor

Chlorocebus sabaeus

green monkey

XM_008003703.2

XP_008001894.1

103252117

BDNF

brain-derived neurotrophic factor

Carlito syrichta

Philippine tarsier

XM_008050727.1

XP_008048918.1

103292699

BDNF

brain-derived neurotrophic factor

Eptesicus fuscus

big brown bat

XM_008148947.2

XP_008147169.1

103552694

BDNF

brain-derived neurotrophic factor

Equus przewalskii

Przewalski’s horse

XM_008522855.1

XP_008521077.1

103599960

BDNF

brain-derived neurotrophic factor

Galeopterus variegatus

Sunda flying lemur

XM_008584165.1

XP_008582387.1

103659367

BDNF

brain-derived neurotrophic factor

Ursus maritimus

polar bear

XM_008686880.2

XP_008685102.2

103748489

Bdnf

brain-derived neurotrophic factor

Nannospalax galili

Upper Galilee mountains blind mole-rat

XM_029555090.1

XP_029410950.1

104671126

BDNF

brain-derived neurotrophic factor

Rhinopithecus roxellana

golden snub-nosed monkey

XM_010374529.2

XP_010372831.1

104873642

Bdnf

brain-derived neurotrophic factor

Fukomys damarensis

Damara mole-rat

XM_033764060.1

XP_033619951.1

104982427

BDNF

brain-derived neurotrophic factor

Bison bison bison

 

XM_010831788.1

XP_010830090.1

105076551

BDNF

brain-derived neurotrophic factor

Camelus bactrianus

Bactrian camel

XM_010964743.1

XP_010963045.1

105106448

BDNF

brain-derived neurotrophic factor

Camelus dromedarius

Arabian camel

XM_031459858.1

XP_031315718.1

105293721

BDNF

brain-derived neurotrophic factor

Pteropus vampyrus

large flying fox

XM_011362565.2

XP_011360867.1

105463281

BDNF

brain-derived neurotrophic factor

Macaca nemestrina

pig-tailed macaque

XM_011710310.2

XP_011708612.1

105507710

BDNF

brain-derived neurotrophic factor

Colobus angolensis palliatus

XM_011936307.1

XP_011791697.1

105528120

BDNF

brain-derived neurotrophic factor

Mandrillus leucophaeus

drill

XM_011964715.1

XP_011820105.1

105572781

BDNF

brain-derived neurotrophic factor

Cercocebus atys

sooty mangabey

XM_012031697.1

XP_011887087.1

105717219

BDNF

brain-derived neurotrophic factor

Aotus nancymaae

Ma’s night monkey

XM_012452238.1

XP_012307661.1

105814556

BDNF

brain-derived neurotrophic factor

Propithecus coquereli

Coquerel’s sifaka

XM_012649556.1

XP_012505010.1

105860148

BDNF

brain-derived neurotrophic factor

Microcebus murinus

gray mouse lemur

XM_020286534.1

XP_020142123.1

105988089

Bdnf

brain-derived neurotrophic factor

Dipodomys ordii

Ord’s kangaroo rat

XM_013019592.1

XP_012875046.1

106824927

BDNF

brain-derived neurotrophic factor

Equus asinus

ass

XM_014831462.1

XP_014686948.1

106970278

BDNF

brain-derived neurotrophic factor

Acinonyx jubatus

cheetah

XM_027072960.1

XP_026928761.1

107134338

Bdnf

brain-derived neurotrophic factor

Marmota marmota marmota

Alpine marmot

XM_015476449.1

XP_015331935.1

107512170

BDNF

brain-derived neurotrophic factor

Rousettus aegyptiacus

Egyptian rousette

XM_036221046.1

XP_036076939.1

107531942

BDNF

brain-derived neurotrophic factor

Miniopterus natalensis

 

XM_016206154.1

XP_016061640.1

108311306

BDNF

brain-derived neurotrophic factor

Cebus imitator

Panamanian white-faced capuchin

XM_017538722.1

XP_017394211.1

108401589

BDNF

brain-derived neurotrophic factor

Manis javanica

Malayan pangolin

XM_017667612.2

XP_017523101.2

108519651

BDNF

brain-derived neurotrophic factor

Rhinopithecus bieti

black snub-nosed monkey

XM_017858805.1

XP_017714294.1

109271282

BDNF

brain-derived neurotrophic factor

Panthera pardus

leopard

XM_019456577.1

XP_019312122.1

109387036

BDNF

brain-derived neurotrophic factor

Hipposideros armiger

great roundleaf bat

XM_019650718.1

XP_019506263.1

109569212

BDNF

brain-derived neurotrophic factor

Bos indicus

zebu cattle

XM_019974522.1

XP_019830081.1

109695020

Bdnf

brain-derived neurotrophic factor

Castor canadensis

American beaver

XM_020177315.1

XP_020032904.1

110143608

BDNF

brain-derived neurotrophic factor

Odocoileus virginianus texanus

XM_020903256.1

XP_020758915.1

110202027

BDNF

brain-derived neurotrophic factor

Phascolarctos cinereus

koala

XM_020977976.1

XP_020833635.1

110285237

Bdnf

brain-derived neurotrophic factor

Mus caroli

Ryukyu mouse

XM_021151236.2

XP_021006895.1

110318089

Bdnf

brain-derived neurotrophic factor

Mus pahari

shrew mouse

XM_021192829.2

XP_021048488.1

110576669

BDNF

brain-derived neurotrophic factor

Neomonachus schauinslandi

Hawaiian monk seal

XM_021685880.1

XP_021541555.1

111150176

LOC111150176

brain-derived neurotrophic factor

Enhydra lutris kenyoni

 

XM_022507574.1

XP_022363282.1

111179820

BDNF

brain-derived neurotrophic factor

Delphinapterus leucas

beluga whale

XM_022583733.1

XP_022439441.1

111554690

BDNF

brain-derived neurotrophic factor

Piliocolobus tephrosceles

Ugandan red Colobus

XM_023230347.2

XP_023086115.1

112303343

BDNF

brain-derived neurotrophic factor

Desmodus rotundus

common vampire bat

XM_024558903.1

XP_024414671.1

112412908

BDNF

brain-derived neurotrophic factor

Neophocaena asiaeorientalis asiaeorientalis

Yangtze finless porpoise

XM_024764694.1

XP_024620462.1

112607193

BDNF

brain-derived neurotrophic factor

Theropithecus gelada

gelada

XM_025358305.1

XP_025214090.1

112667789

BDNF

brain-derived neurotrophic factor

Canis lupus dingo

dingo

XM_025459816.2

XP_025315601.1

112829628

BDNF

brain-derived neurotrophic factor

Callorhinus ursinus

northern fur seal

XM_025879326.1

XP_025735111.1

112865997

BDNF

brain-derived neurotrophic factor

Puma concolor

puma

XM_025929035.1

XP_025784820.1

112935019

BDNF

brain-derived neurotrophic factor

Vulpes vulpes

red fox

XM_026018600.1

XP_025874385.1

113199355

Bdnf

brain-derived neurotrophic factor

Urocitellus parryii

Arctic ground squirrel

XM_026412272.1

XP_026268057.1

113265088

BDNF

brain-derived neurotrophic factor

Ursus arctos horribilis

 

XM_026512203.1

XP_026367988.1

113624889

BDNF

brain-derived neurotrophic factor

Lagenorhynchus obliquidens

Pacific white-sided dolphin

XM_027115138.1

XP_026970939.1

113905455

BDNF

brain-derived neurotrophic factor

Bos indicus x Bos taurus

hybrid cattle

XM_027562786.1

XP_027418587.1

113913517

BDNF

brain-derived neurotrophic factor

Zalophus californianus

California sea lion

XM_027577807.1

XP_027433608.1

114036167

BDNF

brain-derived neurotrophic factor

Vombatus ursinus

common wombat

XM_027852578.1

XP_027708379.1

114093712

Bdnf

brain-derived neurotrophic factor

Marmota flaviventris

yellow-bellied marmot

XM_027936596.1

XP_027792397.1

114220007

BDNF

brain-derived neurotrophic factor

Eumetopias jubatus

Steller sea lion

XM_028117708.1

XP_027973509.1

114500881

BDNF

brain-derived neurotrophic factor

Phyllostomus discolor

pale spear-nosed bat

XM_028517638.2

XP_028373439.1

114620789

Bdnf

brain-derived neurotrophic factor

Grammomys surdaster

 

XM_028766921.1

XP_028622754.1

114702098

Bdnf

brain-derived neurotrophic factor

Peromyscus leucopus

white-footed mouse

XM_037204438.1

XP_037060333.1

114886864

BDNF

brain-derived neurotrophic factor

Monodon monoceros

narwhal

XM_029207934.1

XP_029063767.1

115306639

BDNF

brain-derived neurotrophic factor

Suricata suricatta

meerkat

XM_029957152.1

XP_029813012.1

115525821

BDNF

brain-derived neurotrophic factor

Lynx canadensis

Canada lynx

XM_030333208.1

XP_030189068.1

115857612

BDNF

brain-derived neurotrophic factor

Globicephala melas

long-finned pilot whale

XM_030864833.1

XP_030720693.1

116090620

Bdnf

brain-derived neurotrophic factor

Mastomys coucha

southern multimammate mouse

XM_031371313.1

XP_031227173.1

116476405

BDNF

brain-derived neurotrophic factor

Hylobates moloch

silvery gibbon

XM_032166370.1

XP_032022261.1

116555191

BDNF

brain-derived neurotrophic factor

Sapajus apella

tufted capuchin

XM_032283691.1

XP_032139582.1

116599082

BDNF

brain-derived neurotrophic factor

Mustela erminea

ermine

XM_032358760.1

XP_032214651.1

116638304

BDNF

brain-derived neurotrophic factor

Phoca vitulina

harbor seal

XM_032414183.1

XP_032270074.1

116758559

BDNF

brain-derived neurotrophic factor

Phocoena sinus

vaquita

XM_032641481.1

XP_032497372.1

116881443

BDNF

brain-derived neurotrophic factor

Lontra canadensis

Northern American river otter

XM_032881246.1

XP_032737137.1

116901726

Bdnf

brain-derived neurotrophic factor

Rattus rattus

black rat

XM_032903861.1

XP_032759752.1

117029758

BDNF

brain-derived neurotrophic factor

Rhinolophus ferrumequinum

greater horseshoe bat

XM_033118944.1

XP_032974835.1

117080419

BDNF

brain-derived neurotrophic factor

Trachypithecus francoisi

Francois’s langur

XM_033205475.1

XP_033061366.1

117704234

Bdnf

brain-derived neurotrophic factor

Arvicanthis niloticus

African grass rat

XM_034496309.1

XP_034352200.1

118015716

BDNF

brain-derived neurotrophic factor

Mirounga leonina

Southern elephant seal

XM_035012477.1

XP_034868368.1

118546649

BDNF

brain-derived neurotrophic factor

Halichoerus grypus

gray seal

XM_036109493.1

XP_035965386.1

118582264

Bdnf

brain-derived neurotrophic factor

Onychomys torridus

southern grasshopper mouse

XM_036184983.1

XP_036040876.1

118628031

BDNF

brain-derived neurotrophic factor

Molossus molossus

Pallas’s mastiff bat

XM_036258707.1

XP_036114600.1

118664943

BDNF

brain-derived neurotrophic factor

Myotis myotis

 

XM_036325692.1

XP_036181585.1

118713266

BDNF

brain-derived neurotrophic factor

Pipistrellus kuhlii

Kuhl’s pipistrelle

XM_036427676.1

XP_036283569.1

118853508

BDNF

brain-derived neurotrophic factor

Trichosurus vulpecula

common brushtail

XM_036763631.1

XP_036619526.1

118900201

BDNF

brain-derived neurotrophic factor

Balaenoptera musculus

Blue whale

XM_036862552.1

XP_036718447.1

118909009

BDNF

brain-derived neurotrophic factor

Manis pentadactyla

Chinese pangolin

XM_036879079.1

XP_036734974.1

118983123

BDNF

brain-derived neurotrophic factor

Sturnira hondurensis

 

XM_037040421.1

XP_036896316.1

119049902

BDNF

brain-derived neurotrophic factor

Artibeus jamaicensis

Jamaican fruit-eating bat

XM_037146035.1

XP_037001930.1

119255407

BDNF

brain-derived neurotrophic factor

Talpa occidentalis

Iberian mole

XM_037522538.1

XP_037378435.1

119536361

BDNF

brain-derived neurotrophic factor

Choloepus didactylus

southern two-toed sloth

XM_037839114.1

XP_037695042.1

119815449

Bdnf

brain-derived neurotrophic factor

Arvicola amphibius

Eurasian water vole

XM_038331579.1

XP_038187507.1

119943514

BDNF

brain-derived neurotrophic factor

Tachyglossus aculeatus

Australian echidna

XM_038764545.1

XP_038620473.1

120220096

BDNF

brain-derived neurotrophic factor

Hyaena hyaena

striped hyena

XM_039217098.1

XP_039073029.1

120605221

BDNF

brain-derived neurotrophic factor

Pteropus giganteus

Indian flying fox

XM_039866065.1

XP_039721999.1

120876831

BDNF

brain-derived neurotrophic factor

Oryx dammah

scimitar-horned oryx

XM_040258919.1

XP_040114853.1

121043625

BDNF

brain-derived neurotrophic factor

Puma yagouaroundi

jaguarundi

XM_040495572.1

XP_040351506.1

121156520

BDNF

brain-derived neurotrophic factor

Ochotona curzoniae

black-lipped pika

XM_040980297.1

XP_040836231.1

121465693

Bdnf

brain-derived neurotrophic factor

Microtus oregoni

creeping vole

XM_041679035.1

XP_041534969.1

121476611

BDNF

brain-derived neurotrophic factor

Vulpes lagopus

Arctic fox

XM_041730708.1

XP_041586642.1