Table 2 Association between Age at onset of depression and early life factors during childhood, Depression PRS.

From: The interaction of early life factors and depression-associated loci affecting the age at onset of the depression

Outcome variable

Environment factor

Instrumental variable

Environment factor

Depression PRS

Environment factor * Depression PRS

Beta

SE

T

P-value

Beta

SE

T

P-value

Beta

SE

T

P-value

Age at onset of depression for all participants

Felt hated by family member

−7.385

0.379

−19.506

2.00 × 10−16

−0.287

0.370

−0.776

4.38 × 10−1

0.033

0.347

0.094

9.25 × 10−1

Physically abused by family

−4.538

0.552

−8.217

2.00 × 10−16

0.251

0.533

0.470

6.38 × 10−1

−0.550

0.518

−1.062

2.88 × 10−1

Felt loved

5.534

0.271

20.446

2.00 × 10−16

−1.601

0.485

−3.304

9.55 × 10−4

0.708

0.252

2.806

5.03 × 10−3

Sexually molested

−5.028

0.683

−7.367

1.77 × 10−13

0.102

0.570

0.179

8.58 × 10−1

−0.383

0.556

−0.689

4.91 × 10−1

Mother smoking

−0.087

0.159

−0.547

5.84 × 10−1

−0.326

0.224

−1.458

1.45 × 10−1

−0.001

0.160

−0.008

9.94 × 10−1

Age at onset of depression for females

Felt hated by family member

−7.805

0.445

−17.523

2.00 × 10−16

−0.438

0.442

−0.991

3.22 × 10−1

0.101

0.411

0.245

8.06 × 10−1

Physically abused by family

−5.087

0.692

−7.348

2.07 × 10−13

−0.241

0.686

−0.351

7.26 × 10−1

−0.123

0.667

−0.184

8.54 × 10−1

Felt loved

6.352

0.341

18.610

2.00 × 10−16

−0.742

0.603

−1.230

2.19 × 10−1

0.232

0.314

0.740

4.60 × 10−1

Sexually molested

−4.975

0.732

−6.801

1.06 × 10−11

−0.001

0.611

−0.001

9.99 × 10−1

−0.340

0.591

−0.576

5.64 × 10−1

Mother smoking

−0.224

0.199

−1.123

2.61 × 10−1

−0.317

0.279

−1.133

2.57 × 10−1

−0.039

0.201

−0.194

8.47 × 10−1

Age at onset of depression for males

Felt hated by family member

−6.270

0.713

−8.795

2.00 × 10−16

0.023

0.674

0.035

9.72 × 10−1

−0.131

0.641

−0.204

8.38 × 10−1

Physically abused by family

−3.553

0.914

−3.888

1.01 × 10−4

1.033

0.848

1.219

2.23 × 10−1

−1.207

0.821

−1.470

1.42 × 10−1

Felt loved

4.181

0.444

9.424

2.00 × 10−16

−2.860

0.812

−3.525

4.26 × 10−4

1.421

0.422

3.366

7.64 × 10−4

Sexually molested

−5.574

1.911

−2.916

3.55 × 10−3

0.012

1.667

0.007

9.94 × 10−1

−0.188

1.655

−0.114

9.10 × 10−1

Mother smoking

0.212

0.263

0.808

4.19 × 10−1

−0.316

0.373

−0.849

3.96 × 10−1

0.046

0.265

0.175

8.61 × 10−1

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