Table 2 In the analysis of herpes simplex virus 1 (HSV1) immunoglobulin G (IgG) status (HSV1 antibody positivity/negativity; HSV1+/HSV1−) on regional cortical volumes among patients with severe mental illness (n = 420), we ran 34 sex-, age- and scanner-adjusted analyses of covariance (ANCOVAs) by hemisphere.

	ANCOVAs (HSV1+/HSV1−)				ICV-corrected ANCOVAs	Multiple regressions (HSV1 levels)
	Direction	p values	q values	Partial eta²	p values	p values
Left regional cortical volumes
Caudal middle frontal	–^a	0.0001^b	0.005	0.034	0.001	0.003
Precentral	–	0.001^b	0.017	0.025	0.007	0.003
Lingual	–	0.003^b	0.034	0.021	0.014	0.002
Middle temporal	–	0.005^b	0.043	0.019	0.033	0.027
Banks of superior temporal sulcus	–	0.007^b	0.048	0.017	0.037	0.002
Supramarginal	–	0.015	ns^c
Postcentral	–	0.019	ns
Rostral anterior cingulate	–	0.026	ns
Frontal pole	–	0.044	ns
Right regional cortical volumes
Lingual	–	0.007	ns
Pars opercularis	–	0.008	ns
Precentral	–	0.015	ns
Paracentral	–	0.023	ns
Caudal middle frontal	–	0.036	ns
Superior frontal	–	0.036	ns
Frontal pole	–	0.038	ns
Fusiform	–	0.044	ns
Postcentral	–	0.044	ns

The p values of all nominally significant associations are presented. Applying a false discovery rate (FDR) of 5% by hemisphere to correct for multiple testing, HSV1+ patients had significantly smaller left caudal middle frontal, left precentral, left lingual, left middle temporal and left banks of superior temporal sulcus volumes compared with HSV1− patients. For the significant associations q values, effect sizes (partial eta²), p values from sex-, age-, scanner- and estimated intracranial volumes (ICV)- corrected ANCOVAs as well as p values from sex-, age- and scanner-adjusted multiple regressions of the HSV1 levels on regional volumes are presented.
^aSmaller regional volumes in HSV1+ patients compared with HSV1− patients.
^bSurvives FDR correction.
^cNon-significant.

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