Fig. 4: Investigation of the effect of altered BRD1 expression on mitochondrial amount. | Translational Psychiatry

Fig. 4: Investigation of the effect of altered BRD1 expression on mitochondrial amount.

From: The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation

Fig. 4

A Mitochondrial DNA content relative to the mean of two nuclear reference genes (GAPDH and SLC34A2) (n = 3/group). b Mitochondrial mass (n = 3/group). Control: naïve HEK293T cells, BRD1CRISPRex6/+: Clone #3 of BRD1CRISPRex6/+ HEK293T cells, BRD1-L: HEK293T cells stably overexpressing the BRD1-L isoform, BRD1-S: HEK293T cells stably overexpressing the BRD1-S isoform. Data presented as mean ± SEM. P-value as determined using ANOVA (brackets). p < 0.001 (***); not significant (ns).

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