Fig. 3: GADD45 family genes are differentially expressed in Egr3−/− mice. | Translational Psychiatry

Fig. 3: GADD45 family genes are differentially expressed in Egr3−/− mice.

From: Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia

Fig. 3: GADD45 family genes are differentially expressed in Egr3−/− mice.

A, B Expression microarray results of GADD45B pathway gene expression in hippocampus from WT and Egr3−/− mice at baseline (No ECS) and 1 h after ECS. A Gadd45b, B Gadd45g. Quantitative RT-PCR validation of Gadd45b in (C) the original male cohort and (D) the replication female cohort. E qRT-PCR validation of Gadd45g results in original male cohort. (For experiments in A–C and E n = 4 animals/group, experiments in D WT: No ECS, n = 4; 1 h after ECS, n = 5; Egr3−/−: No ECS, n = 4; 1 h after ECS, n = 5; *p < 0.05, **p < 0.01, ***p < 0.001, controlled for multiple comparisons, values represent means ± SEM). Statistical analyses for these, and all subsequent graphs, are shown in Table 3.

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