Table 3 Statistics for microarray and qRT-PCR analyses.

From: Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia

Gene

Two-way ANOVA results

Post hoc comparison (Tukey’s test) results (p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

Gadd45b (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 18.39, p = 0.0011

WT vs WT ECS ***, WT ECS vs KO ECS ***

Gadd45b (M, qRT PCR)

Sig interaction of genotype & treatment F (1, 12) = 12.55, p = 0.0041

WT vs WT ECS ***, WT ECS vs KO ECS **

Gadd45b (F, qRT PCR)

Sig effect of genotype F (1, 14) = 5.302, p = 0.0372;

Sig effect of treatment F (1, 14) = 15.80, p = 0.0014

WT vs WT ECS **, WT ECS vs KO ECS *

Gadd45g (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 18.39, p = 0.0011

WT vs WT ECS ***, WT ECS vs KO ECS **

Gadd45g (M, qRT PCR)

Sig interaction of genotype & treatment F (1, 12) = 9.875, p = 0.0085

WT vs WT ECS ***, WT ECS vs KO ECS *

Gadd45g (F, qRT PCR)

Not sig

N/A

Cdnk1a (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 7.316, p = 0.0191

WT vs WT ECS ****, KO vs KO ECS *, WT ECS vs KO ECS *

Cenpa (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 263.1, p < 0.0001

WT vs WT ECS ****, WT ECS vs KO ECS ****

Cenpa (M, qRT PCR)

Sig interaction of genotype & treatment F (1, 12) = 103.9, p < 0.0001

WT vs WT ECS ****, WT ECS vs KO ECS ****

Cenpa (F, qRT PCR)

Sig interaction of genotype & treatment F (1, 14) = 68.28, p < 0.0001

WT vs WT ECS ****, WT ECS vs KO ECS ****

Fos (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 10.92, p = 0.0063

WT vs WT ECS ****, KO vs KO ECS *, WT ECS vs KO ECS**

Fos (M, qRT PCR)

Sig interaction of genotype & treatment F (1, 12) = 5.808, p = 0.0329

WT vs WT ECS **, WT ECS vs KO ECS *

Fos (F, qRT PCR)

Sig effect of treatment F (1, 14) = 8.392, p = 0.0117

WT vs WT ECS *

Fosb (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 63.79, p < 0.0001

WT vs WT ECS ****, WT ECS vs KO ECS ****

Fosb (M, qRT PCR)

Sig interaction of genotype & treatment F (1, 12) = 14.01, p = 0.0028

WT vs WT ECS ***, WT ECS vs KO ECS ***

Fosb (F, qRT PCR)

Sig interaction of genotype & treatment F (1, 14) = 7.094, p = 0.0185

WT vs WT ECS ***, WT ECS vs KO ECS **

Junb (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 18.22, p = 0.0011

WT vs WT ECS ****, KO vs KO ECS *, WT ECS vs KO ECS***

Junb (M, qRT PCR)

Sig effect of treatment F (1, 12) = 6.247, p = 0.0280

Posthoc comparisons NS

Junb (F, qRT PCR)

Sig effect of treatment F (1, 14) = 6.569, p = 0.0225; sig

effect of genotype F (1, 14) = 4.608, p = 0.0498

Posthoc comparisons NS

Nr4a2 (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 15.90, p = 0.0018

WT vs WT ECS ***, WT ECS vs KO ECS ***

Nr4a2 (M, qRT PCR)

Sig interaction of genotype & treatment F (1, 12) = 7.050, p = 0.0210

WT vs WT ECS ***, WT ECS vs KO ECS **

Nr4a2 (F, qRT PCR)

Sig interaction of genotype & treatment F (1, 14) = 5.230, p = 0.0383

WT vs WT ECS *

Mef2c (M, microarray)

Sig interaction of genotype & treatment F (1, 12) = 21.07, p = 0.0006

WT vs WT ECS**, KO vs. WT ECS**

Mef2c (M, qRT PCR)

Sig interaction of genotype & treatment F (1, 12) = 9.484, p = 0.0095

Posthoc comparisons NS

Mef2c (F, qRT PCR)

Not sig

N/A

Calb2 (M, microarray)

Sig effect of genotype F (1, 12) = 48.99, p < 0.0001

WT vs KO***, WT ECS vs. KO ECS**

Calb2 (M, qRT PCR)

Sig effect of genotype F (1, 12) = 11, p = 0.0061

Posthoc comparisons NS

Calb2 (F, qRT PCR)

Not sig

N/A

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