Table 2 FUMA top 10 gene ontology (GO) and canonical pathway enrichment categories of ~1,183 genes that map to differentially methylated probes in primary EWAS (left) and comparable gene list from supplementary EWAS that included all CpGs regardless of blood-brain correlation (right).

1

Biological adhesion^b

7.88E−26

5.79E−22

Neurogenesis

1.70E−32

1.25E−28

2

Homophilic cell adhesion via plasma membrane adhesion molecules

1.37E−24

5.04E−21

Neuron differentiation

2.47E−27

9.08E−24

3

Cell–cell signalling

4.77E−24

1.17E−20

Positive regulation of biosynthetic process

1.78E−26

4.37E−23

4

Cell–cell adhesion via plasma membrane adhesion molecules

2.20E−23

4.05E−20

Positive regulation of gene expression

4.99E−24

9.18E−21

5

Cell–cell adhesion

4.78E−22

7.03E−19

Central nervous system development

2.25E−23

3.31E−20

6

Synaptic signalling

8.10E−18

9.92E−15

Sensory organ development

7.72E−23

9.46E−20

7

Ion transport

1.53E−16

1.61E−13

Positive regulation of RNA biosynthetic process

1.43E−22

1.51E−19

8

Positive regulation of molecular function

4.19E−15

3.85E−12

Animal organ morphogenesis

4.63E−22

4.25E−19

9

Synapse assembly

1.63E−14

1.33E−11

Biological adhesion^b

1.24E−21

1.01E−18

10

Synapse organization

6.41E−14

4.71E−11

Growth

1.62E−21

1.19E−18

1

Intrinsic component of plasma membrane

2.26E−26

2.26E−23

Neuron part^b

3.48E−28

3.48E−25

2

Synapse^b

8.30E−22

4.16E−19

Cell junction^b

1.23E−21

6.17E−19

3

Neuron part^b

2.66E−19

8.88E−17

Plasma membrane region^b

1.16E−19

3.14E−17

4

Cell junction^b

1.53E−18

3.83E−16

Synapse^b

1.33E−19

3.14E−17

5

Synapse part^b

2.05E−17

4.11E−15

Neuron projection^b

1.57E−19

3.14E−17

6

Neuron projection^b

3.68E−16

6.15E−14

Cell projection part^b

1.56E−18

2.60E−16

7

Plasma membrane region^b

2.81E−15

4.01E−13

Intrinsic component of plasma membrane

7.63E−17

1.09E−14

8

Postsynapse

1.35E−14

1.68E−12

Somatodendritic compartment

1.82E−16

2.27E−14

9

Cell projection part^b

8.84E−14

9.84E−12

Cytoskeletal part

5.43E−16

6.04E−14

10

Whole membrane

4.82E−13

4.82E−11

Synapse part^b

2.69E−15

2.70E−13

1

Calcium ion binding

5.41E−22

8.91E−19

Sequence-specific DNA binding^b

1.15E−22

1.90E−19

2

Ribonucleotide binding^b

2.23E−13

1.83E−10

Regulatory region nucleic acid binding^b

2.96E−20

2.43E−17

3

Drug binding^b

3.09E−12

1.70E−09

DNA binding transcription factor activity

1.37E−18

7.49E−16

4

Adenyl nucleotide binding

2.41E−11

9.91E-09

Sequence-specific double-stranded DNA binding^b

2.59E−18

1.06E−15

5

Sequence-specific DNA binding^b

3.01E−10

9.28E−08

Double-stranded DNA binding^b

3.60E−18

1.19E−15

6

Regulatory region nucleic acid binding^b

3.54E−10

9.28E−08

Drug binding^b

7.84E−17

2.01E−14

7

Transmembrane transporter activity

3.95E−10

9.28E−08

Ribonucleotide binding^b

8.55E−17

2.01E−14

8

Double-stranded DNA binding^b

7.90E−10

1.62E−07

Adenyl nucleotide binding

5.06E−16

1.04E−13

9

Sequence-specific double-stranded DNA binding^b

1.17E−09

2.13E−07

Cytoskeletal protein binding

7.90E−16

1.44E−13

10

Ion transmembrane transporter activity

1.84E−09

2.76E−07

Identical protein binding

2.24E−14

3.69E−12

1

Neuronal system^b

7.87E−17

1.73E−13

Neuronal system^b

8.06E−12

1.77E−08

2

Protein protein^b interactions at synapses

5.20E−13

5.71E−10

Extracellular matrix organization

1.03E−10

1.13E−07

3

Transmission across chemical synapses^b

8.46E−11

6.20E−08

Transport of small molecules

1.31E−08

9.61E−06

4

Neurotransmitter receptors and postsynaptic signal transmission^b

1.66E−10

9.10E−08

Axon guidance

2.90E−08

1.38E−05

5

Neurexins and neuroligins

2.21E−10

9.71E−08

Developmental biology

3.14E−08

1.38E−05

6

Activation of NMDA receptors and postsynaptic events

6.95E−09

2.55E−06

NABA matrisome^b

4.42E−08

1.62E−05

7

Disease

1.88E−07

5.92E−05

Signalling by receptor tyrosine kinases

1.43E−07

4.17E−05

8

NABA core matrisome^b

1.39E−06

0.000382

Protein protein interactions at synapses^b

1.52E−07

4.17E−05

9

CREB1 phosphorylation through NMDAR-mediated activation of RAS signalling

2.21E−06

0.00054

Neurotransmitter receptors and postsynaptic signal transmission^b

3.14E−07

7.29E−05

10

GPCR ligand binding

2.94E−06

0.000598

Transmission across chemical synapses^b

3.32E−07

7.29E−05