Table 3 Comparison of geometric parameters of the femur among four groups.

From: Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress – an animal model of depression

Group

Cross section

area (mm2)

Second moment of area in x-direction

Ix (xCSMI) (mm4)†

Second moment of area in y-direction

Iy (yCSMI) (mm4) †

Polar moment of inertia in z-direction

Iz = Ix + Iy (mm4) †

Vertical outer diameter (mm)

Horizontal outer diameter (mm)

Vertical inner diameter (mm)

Horizontal inner diameter (mm)

Average midshaft thickness (mm)

Control group (No CMS + No oral gavage)

6.32 ± 0.49

4.69 ± 0.83

7.13 ± 0.83

11.82 ± 1.50

3.01 ± 0.22

3.78 ± 0.13

1.46 ± 0.39

2.23 ± 0.23

0.78 ± 0.10

Fluoxetine-only group (10 mg/kg)

9.37 ± 0.31

(p = 0.0797)

6.22 ± 0.29

(p = 0.4407)

12.04 ± 1.00*

(p = 0.0298)

18.08 ± 1.25

(p = 0.0599)

3.05 ± 0.09

(p = 0.8711)

4.36 ± 0.12*

(p = 0.0488)

0.81 ± 0.23

(p = 0.0504)

2.12 ± 0.28

(p = 0.9465)

1.12 ± 0.13**

(p = 0.00047)

CMS + placebo group

7.55 ± 1.19

(p = 0.7534)

5.28 ± 1.51

(p = 0.9179)

9.10 ± 3.20

(p = 0.5128)

14.38 ± 4.63

(p = 0.6248)

3.01 ± 0.23

(p = 0.9999)

3.97 ± 0.44

(p = 0.7534)

1.11 ± 0.38

(p = 0.3009)

2.07 ± 0.45

(p = 0.9057)

0.95 ± 0.13

(p = 0.0506)

CMS + Fluoxetine group (10 mg/kg)

7.19 ± 1.45

(p = 0.7216)

5.20 ± 2.00

(p = 0.9096)

8.97 ± 3.37

(p = 0.5682)

14.18 ± 5.19

(p = 0.6838)

2.96 ± 0.42

(p = 0.9904)

3.99 ± 0.48

(p = 0.7216)

1.18 ± 0.41

(p = 0.4922)

2.21 ± 0.56

(p = 0.9997)

0.89 ± 0.13

(p = 0.2976)

  1. *p < 0.05, **p < 0.001, †Explanation of Ix, Iy and Iz can be found in Supplementary Fig. 1.
Back to article page