Fig. 1: Expression levels of analyzed miRNAs in Alzheimer’s disease patients relative to controls.
From: Differential microRNA expression analyses across two brain regions in Alzheimer’s disease
a Superior temporal gyrus (STG) samples analyzed by qPCR. b Entorhinal cortex (EC) samples analyzed by small RNA sequencing. Bars filled in light gray: controls; bars filled in dark gray: AD cases; *: statistically significant difference at α = 0.0167 (see “Methods”). The relative quantity of miRNA expression was calculated using the ΔΔCt method; diamonds represent the mean expression (cases relative to controls) based on the ΔΔCt method (relative quantity = 2(−(dCt cases - dCt controls))). Horizontal lines represent median values of the corresponding sample-specific values (individual dCt values normalized to the mean of the control samples), boxes represent interquartile ranges, and whiskers extend to the minimum and maximum observed value within 1.5x the interquartile range; values outside this range but below the dashed line are depicted as dots. The box notches indicate the 95 % confidence intervals. Outliers exceeding the dashed line are not shown (for scaling purposes) but counted and indicated by the numbers in the triangles.
