Table 2 Lead SNPs in top loci associated with PTSD cases in the discovery cohort (CCSS) and their results in the replication cohort (SJLIFE) and in meta-analysisa.

From: Genome-wide association study of posttraumatic stress disorder among childhood cancer survivors: results from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort

        

Model 1b

Model 2c

Chr

Position

SNP

Gene

A1

A2

Sample

RAF

OR (95% CI)

P

OR (95% CI)

P

10

135208461

rs34713356

MTG1

A

G

CCSS

0.14

1.57 (1.35–1.84)

1.36 × 10–8

1.61 (1.37–1.90)

6.41 × 10–9

      

SJLIFE

0.15

1.37 (1.00–1.87)

0.047

1.39 (0.99–1.95)

0.058

      

Meta-analysis

-

1.53 (1.34–1.75)

8.55 × 10–10

1.57 (1.36–1.82)

1.38 × 10–9

6

148472854

rs9390543

SASH1

G

A

CCSS

0.45

0.75 (0.67–0.85)

3.56 × 10–6

0.74 (0.65–0.84)

1.86 × 10–6

      

SJLIFE

0.43

0.74 (0.58–0.93)

0.011

0.74 (0.58–0.96)

0.02

      

Meta-analysis

-

0.75 (0.68–0.83)

2.02 × 10–8

0.74 (0.66–0.83)

1.18 × 10–7

  1. A1 Risk allele, A2 reference allele, CCSS Childhood Cancer Survivor Study, Chr chromosome, CI confidence interval, OR odds ratio, PTSD posttraumatic stress disorder, RAF risk allele frequency, SJLIFE St. Jude Lifetime Study, SNP single-nucleotide polymorphism.
  2. aIndex variants are linkage disequilibrium independent (r2 < 0.1) and are merged into 1 locus when located with a distance less than 400 kilobases. Genes were mapped in either positional (i.e., SNPs physically located inside a gene with up to 200 kilobase windows) or eQTL mapping (based on brain and blood samples from GTEx project as described previously).
  3. bEstimates were adjusted for sex and top 10 principal components.
  4. cEstimates were additional adjusted for age at cancer diagnosis, cancer type, surgery, chemotherapy, radiotherapy, educational level, employment status, personal income, and marital status.
Back to article page